RFC2

RFC2
Identifiers
Aliases	RFC2, RFC40, replication factor C subunit 2
External IDs	OMIM: 600404; MGI: 1341868; HomoloGene: 6885; GeneCards: RFC2; OMA:RFC2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	74,254,458 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	134,630,659 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; gonad; ; monocyte; ; granulocyte; ; muscle of thigh; ; testicle; ; skin of leg; ; mucosa of transverse colon; ; skin of abdomen;
	Top expressed in
	spermatid; ; spermatocyte; ; ventricular zone; ; seminiferous tubule; ; granulocyte; ; fetal liver hematopoietic progenitor cell; ; embryo; ; epiblast; ; abdominal wall; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; DNA binding; single-stranded DNA helicase activity; protein binding; enzyme binding; ATP binding; DNA clamp loader activity;
Cellular component	DNA replication factor C complex; Ctf18 RFC-like complex; nucleoplasm; nucleus;
Biological process	nucleotide-excision repair, DNA gap filling; error-free translesion synthesis; error-prone translesion synthesis; DNA replication; positive regulation of DNA-directed DNA polymerase activity; translesion synthesis; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; DNA repair; telomere maintenance via semi-conservative replication; DNA-dependent DNA replication; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	5982
	19718
	ENSG00000049541
	ENSMUSG00000023104
	P35250; Q75MT5
	Q9WUK4
	NM_001278791; NM_001278792; NM_001278793; NM_002914; NM_181471
	NM_020022
NP_001265720; NP_001265721; NP_001265722; NP_002905; NP_852136;
	NP_002905.2
	NP_064406
	Wikidata
View/Edit Human	View/Edit Mouse

Replication factor C subunit 2 is a protein that in humans is encoded by the RFC2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000049541 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023104 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen M, Pan ZQ, Hurwitz J (Apr 1992). "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells". Proceedings of the National Academy of Sciences of the United States of America. 89 (7): 2516–20. Bibcode:1992PNAS...89.2516C. doi:10.1073/pnas.89.7.2516. PMC 48692. PMID 1313560.
^ Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K (Jan 1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23". Genomics. 25 (1): 274–8. doi:10.1016/0888-7543(95)80135-9. PMID 7774928.
^ "Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000049541 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023104 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1313560-5] Chen M, Pan ZQ, Hurwitz J (Apr 1992). "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells". Proceedings of the National Academy of Sciences of the United States of America. 89 (7): 2516–20. Bibcode:1992PNAS...89.2516C. doi:10.1073/pnas.89.7.2516. PMC 48692. PMID 1313560.

[pmid7774928-6] Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K (Jan 1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23". Genomics. 25 (1): 274–8. doi:10.1016/0888-7543(95)80135-9. PMID 7774928.

[entrez-7] "Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa".

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