RFC4

RFC4
Identifiers
Aliases	RFC4, A1, RFC37, replication factor C subunit 4
External IDs	OMIM: 102577; MGI: 2146571; HomoloGene: 6288; GeneCards: RFC4; OMA:RFC4 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	186,807,058 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	22,946,487 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; gonad; ; rectum; ; testicle; ; cerebellar hemisphere; ; bone marrow; ; right hemisphere of cerebellum; ; mucosa of transverse colon; ; appendix;
	Top expressed in
	medial ganglionic eminence; ; maxillary prominence; ; mandibular prominence; ; otic placode; ; Gonadal ridge; ; abdominal wall; ; otic vesicle; ; fetal liver hematopoietic progenitor cell; ; endocardial cushion; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; DNA binding; single-stranded DNA helicase activity; protein binding; enzyme binding; ATP binding; DNA clamp loader activity;
Cellular component	DNA replication factor C complex; Ctf18 RFC-like complex; nucleus; nucleoplasm; Elg1 RFC-like complex;
Biological process	nucleotide-excision repair, DNA gap filling; error-free translesion synthesis; DNA strand elongation involved in DNA replication; error-prone translesion synthesis; DNA replication; positive regulation of DNA-directed DNA polymerase activity; translesion synthesis; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; DNA repair; telomere maintenance via semi-conservative replication; DNA-dependent DNA replication; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	5984
	106344
	ENSG00000163918
	ENSMUSG00000022881
	P35249
	Q99J62
	NM_181573; NM_002916
	NM_145480
	NP_002907; NP_853551
	NP_663455
	Wikidata
View/Edit Human	View/Edit Mouse

Replication factor C subunit 4 is a protein that in humans is encoded by the RFC4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163918 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022881 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K (Jan 1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23". Genomics. 25 (1): 274–8. doi:10.1016/0888-7543(95)80135-9. PMID 7774928.
^ "Entrez Gene: RFC4 replication factor C (activator 1) 4, 37kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163918 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022881 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7774928-5] Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K (Jan 1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23". Genomics. 25 (1): 274–8. doi:10.1016/0888-7543(95)80135-9. PMID 7774928.

[entrez-6] "Entrez Gene: RFC4 replication factor C (activator 1) 4, 37kDa".

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