RFXANK

RFXANK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UXG, 3V30, 4QQM
Identifiers
Aliases	RFXANK, ANKRA1, BLS, F14150_1, RFX-B, regulatory factor X associated ankyrin containing protein
External IDs	OMIM: 603200; MGI: 1333865; HomoloGene: 2760; GeneCards: RFXANK; OMA:RFXANK - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	19,201,869 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	70,591,804 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right uterine tube; ; right lobe of thyroid gland; ; ventricular zone; ; left lobe of thyroid gland; ; olfactory zone of nasal mucosa; ; granulocyte; ; canal of the cervix; ; apex of heart; ; right ovary;
	Top expressed in
	granulocyte; ; blood; ; interventricular septum; ; cardiac muscle tissue of left ventricle; ; gastric mucosa; ; duodenum; ; lumbar subsegment of spinal cord; ; epithelium of stomach; ; ventricular zone; ; brown adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; transcription coregulator activity; histone deacetylase binding;
Cellular component	nucleus; nucleoplasm; intercellular bridge; cytoplasm; cytosol;
Biological process	regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; transcription, DNA-templated; Ras protein signal transduction; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	8625
	19727
	ENSG00000064490
	ENSMUSG00000036120
	O14593
	Q9Z205
NM_001278727; NM_001278728; NM_003721; NM_134440; NM_001370233;
	NM_001370234; NM_001370235; NM_001370236; NM_001370237; NM_001370238
	NM_001025589; NM_011266
NP_001265656; NP_001265657; NP_003712; NP_604389; NP_001357162;
	NP_001357163; NP_001357164; NP_001357165; NP_001357166; NP_001357167
	NP_001020760; NP_035396
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-binding protein RFXANK is a protein that in humans is encoded by the RFXANK gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000064490 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036120 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Masternak K, Barras E, Zufferey M, Conrad B, Corthals G, Aebersold R, Sanchez JC, Hochstrasser DF, Mach B, Reith W (Nov 1998). "A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients". Nature Genetics. 20 (3): 273–7. doi:10.1038/3081. PMID 9806546. S2CID 23780606.
^ Nagarajan UM, Louis-Plence P, DeSandro A, Nilsen R, Bushey A, Boss JM (Feb 1999). "RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency". Immunity. 10 (2): 153–62. doi:10.1016/S1074-7613(00)80016-3. PMID 10072068.
^ "Entrez Gene: RFXANK regulatory factor X-associated ankyrin-containing protein".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000064490 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036120 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9806546-5] Masternak K, Barras E, Zufferey M, Conrad B, Corthals G, Aebersold R, Sanchez JC, Hochstrasser DF, Mach B, Reith W (Nov 1998). "A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients". Nature Genetics. 20 (3): 273–7. doi:10.1038/3081. PMID 9806546. S2CID 23780606.

[pmid10072068-6] Nagarajan UM, Louis-Plence P, DeSandro A, Nilsen R, Bushey A, Boss JM (Feb 1999). "RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency". Immunity. 10 (2): 153–62. doi:10.1016/S1074-7613(00)80016-3. PMID 10072068.

[entrez-7] "Entrez Gene: RFXANK regulatory factor X-associated ankyrin-containing protein".

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