RIPK1

RIPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ITH, 4ITI, 4ITJ, 4NEU, 5HX6
Identifiers
Aliases	RIPK1, RIP, RIP1, RIP-1, receptor interacting serine/threonine kinase 1, IMD57, AIEFL
External IDs	OMIM: 603453; MGI: 108212; HomoloGene: 2820; GeneCards: RIPK1; OMA:RIPK1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p25.2 Start 3,063,824 bp[1] End 3,115,187 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A3.3|13 14.01 cM Start 34,186,346 bp[2] End 34,221,130 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte sural nerve right lobe of liver stromal cell of endometrium gastric mucosa Achilles tendon right coronary artery skin of abdomen skin of leg apex of heart Top expressed in renal corpuscle Paneth cell endothelial cell of lymphatic vessel granulocyte stroma of bone marrow left lobe of liver epithelium of stomach jejunum conjunctival fornix fetal liver hematopoietic progenitor cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding death domain binding kinase activity protein serine/threonine kinase activity protein binding identical protein binding ATP binding ubiquitin protein ligase binding signal transducer activity protein-containing complex binding death receptor binding JUN kinase kinase kinase activity Cellular component membrane receptor complex plasma membrane mitochondrion death-inducing signaling complex membrane raft cytoplasm cytosol endosome membrane ripoptosome protein-containing complex Biological process T cell apoptotic process positive regulation of protein phosphorylation amyloid fibril formation positive regulation of cell death phosphorylation regulation of ATP:ADP antiporter activity peptidyl-serine autophosphorylation regulation of tumor necrosis factor-mediated signaling pathway positive regulation of macrophage differentiation cellular response to tumor necrosis factor cellular response to growth factor stimulus negative regulation of extrinsic apoptotic signaling pathway positive regulation of programmed cell death tumor necrosis factor-mediated signaling pathway positive regulation of JNK cascade regulation of reactive oxygen species metabolic process negative regulation of I-kappaB kinase/NF-kappaB signaling TRIF-dependent toll-like receptor signaling pathway response to tumor necrosis factor positive regulation of necroptotic process protein phosphorylation positive regulation of reactive oxygen species metabolic process death-inducing signaling complex assembly positive regulation of NF-kappaB transcription factor activity necroptotic signaling pathway positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of extrinsic apoptotic signaling pathway protein autophosphorylation regulation of extrinsic apoptotic signaling pathway via death domain receptors necroptosis positive regulation of phosphorylation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand I-kappaB kinase/NF-kappaB signaling activation of cysteine-type endopeptidase activity involved in apoptotic process protein homooligomerization positive regulation of transcription by RNA polymerase II ripoptosome assembly signal transduction positive regulation of MAPK cascade positive regulation of hydrogen peroxide-induced cell death apoptotic signaling pathway apoptotic process programmed cell death extrinsic apoptotic signaling pathway positive regulation of necrotic cell death negative regulation of extrinsic apoptotic signaling pathway via death domain receptors protein deubiquitination ripoptosome assembly involved in necroptotic process MyD88-independent toll-like receptor signaling pathway toll-like receptor 3 signaling pathway viral process protein heterooligomerization MAPK cascade negative regulation of cardiac muscle cell proliferation cellular response to hydrogen peroxide programmed necrotic cell death positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of production of miRNAs involved in gene silencing by miRNA negative regulation of G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8737 19766 Ensembl ENSG00000137275 ENSMUSG00000021408 UniProt Q13546 Q60855 RefSeq (mRNA) NM_003804 NM_001317061 NM_001354930 NM_001354931 NM_001354932 NM_001354933 NM_001354934 NM_009068 NM_001359997 RefSeq (protein) NP_001303990 NP_003795 NP_001341859 NP_001341860 NP_001341861 NP_001341862 NP_001341863 NP_033094 NP_001346926 Location (UCSC) Chr 6: 3.06 – 3.12 Mb Chr 13: 34.19 – 34.22 Mb PubMed search [3] [4]
Wikidata
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Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions in a variety of cellular pathways related to both cell survival and death. In terms of cell death, RIPK1 plays a role in apoptosis, necroptosis, and PANoptosis Some of the cell survival pathways RIPK1 participates in include NF-κB, Akt, and JNK.^[5]

RIPK1 is an enzyme that in humans is encoded by the RIPK1 gene, which is located on chromosome 6.^[6][7][8] This protein belongs to the Receptor Interacting Protein (RIP) kinases family, which consists of 7 members, RIPK1 being the first member of the family.^[9]