RIPK3

RIPK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4M66, 4M69
Identifiers
Aliases	RIPK3, RIP3, receptor interacting serine/threonine kinase 3
External IDs	OMIM: 605817; MGI: 2154952; HomoloGene: 31410; GeneCards: RIPK3; OMA:RIPK3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,336,025 bp[1] End 24,340,022 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 56,022,452 bp[2] End 56,026,322 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte mucosa of transverse colon blood duodenum spleen rectum appendix monocyte right lobe of thyroid gland lymph node Top expressed in endothelial cell of lymphatic vessel yolk sac thymus Paneth cell internal carotid artery cartilage organ dermis epithelium of small intestine external carotid artery embryo More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding transcription coactivator activity kinase activity protein serine/threonine kinase activity NF-kappaB-inducing kinase activity protein binding identical protein binding ATP binding protein-containing complex binding Cellular component cytoplasm cytosol membrane plasma membrane intracellular anatomical structure mitochondrion Biological process regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation amyloid fibril formation T cell differentiation in thymus protein heterooligomerization phosphorylation thymus development regulation of interferon-gamma production positive regulation of oxidoreductase activity regulation of adaptive immune response spleen development regulation of reactive oxygen species metabolic process regulation of activation-induced cell death of T cells T cell homeostasis positive regulation of phosphatase activity positive regulation of necroptotic process protein phosphorylation regulation of activated T cell proliferation positive regulation of reactive oxygen species metabolic process NIK/NF-kappaB signaling positive regulation of NF-kappaB transcription factor activity apoptotic signaling pathway protein autophosphorylation positive regulation of ligase activity necroptosis regulation of T cell mediated cytotoxicity I-kappaB kinase/NF-kappaB signaling lymph node development protein homooligomerization activation of protein kinase activity positive regulation of intrinsic apoptotic signaling pathway signal transduction programmed cell death positive regulation of necrotic cell death positive regulation of nucleic acid-templated transcription cellular response to hydrogen peroxide programmed necrotic cell death Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11035 56532 Ensembl ENSG00000129465 ENSG00000285379 ENSMUSG00000022221 UniProt Q9Y572 Q9QZL0 RefSeq (mRNA) NM_006871 NM_001164107 NM_001164108 NM_019955 RefSeq (protein) NP_006862 NP_001157579 NP_001157580 NP_064339 Location (UCSC) Chr 14: 24.34 – 24.34 Mb Chr 14: 56.02 – 56.03 Mb PubMed search [3] [4]
Wikidata
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Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that is encoded by the RIPK3 gene in humans.^[5][6][7][8]

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. It contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce necroptosis by interaction with RIPK1 and MLKL in a protein complex termed the necrosome.^[7] Interactions between RIPK1 and RIPK3 also form a necrosome, which triggers apoptosis.^[9]