RNASET2

RNASET2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3T0O
Identifiers
Aliases	RNASET2, RNASE6PL, bA514O12.3, ribonuclease T2
External IDs	OMIM: 612944; MGI: 3702087; HomoloGene: 31190; GeneCards: RNASET2; OMA:RNASET2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	166,957,191 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	7,278,698 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; granulocyte; ; blood; ; monocyte; ; spleen; ; parotid gland; ; seminal vesicula; ; olfactory bulb; ; lymph node; ; inferior ganglion of vagus nerve;
	Top expressed in
	right kidney; ; granulocyte; ; muscle of thigh; ; lip; ; zygote; ; esophagus; ; genital tubercle; ; dentate gyrus of hippocampal formation granule cell; ; ventricular zone; ; morula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; ribonuclease T2 activity; endonuclease activity; nuclease activity; RNA binding; ribonuclease activity; endoribonuclease activity;
Cellular component	lysosomal lumen; endoplasmic reticulum lumen; lysosome; endoplasmic reticulum; extracellular exosome; extracellular region; extracellular space; azurophil granule lumen;
Biological process	nucleic acid phosphodiester bond hydrolysis; RNA phosphodiester bond hydrolysis, endonucleolytic; RNA catabolic process; RNA phosphodiester bond hydrolysis; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	8635
	68195
	ENSG00000026297
	ENSMUSG00000094724
	O00584
	Q5FWA0
	NM_003730; NM_017795; NM_018726
	NM_026611; NM_029204
	NP_003721
	NP_080887; NP_001077407; NP_080887
	Wikidata
View/Edit Human	View/Edit Mouse

Ribonuclease T2 is an enzyme that in humans is encoded by the RNASET2 gene.^[5]^[6] It is a type of endoribonuclease.

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.^[6] RNASET2 has been reported as a tumour associated antigen in anaplastic large cell lymphoma and other lymphomas.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000026297 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000094724 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Trubia M, Sessa L, Taramelli R (Sep 1997). "Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies". Genomics. 42 (2): 342–344. doi:10.1006/geno.1997.4679. PMID 9192857.
^ ^a ^b "Entrez Gene: RNASET2 ribonuclease T2".
^ Patel S, Chen H, Monti L, Gould E, Haralambieva E, Schmid J, Toomey D, Woessmann W, Roncador G, Hatton CS, Liggins AP, Taramelli R, Banham AH, Acquati F, Murphy D, Pulford K (Sep 2012). "RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis". J Proteomics. 75 (17): 5279–5292. doi:10.1016/j.jprot.2012.06.009. PMID 22732457.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000026297 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000094724 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9192857-5] Trubia M, Sessa L, Taramelli R (Sep 1997). "Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies". Genomics. 42 (2): 342–344. doi:10.1006/geno.1997.4679. PMID 9192857.

[entrez-6] "Entrez Gene: RNASET2 ribonuclease T2".

[pmid22732457-7] Patel S, Chen H, Monti L, Gould E, Haralambieva E, Schmid J, Toomey D, Woessmann W, Roncador G, Hatton CS, Liggins AP, Taramelli R, Banham AH, Acquati F, Murphy D, Pulford K (Sep 2012). "RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis". J Proteomics. 75 (17): 5279–5292. doi:10.1016/j.jprot.2012.06.009. PMID 22732457.

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