ROM1

ROM1
Identifiers
Aliases	ROM1, ROM, ROSP1, RP7, TSPAN23, retinal outer segment membrane protein 1
External IDs	OMIM: 180721; MGI: 97998; HomoloGene: 276; GeneCards: ROM1; OMA:ROM1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	62,615,116 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	8,906,720 bp
RNA expression pattern
	Top expressed in
	gonad; ; C1 segment; ; amygdala; ; putamen; ; caudate nucleus; ; nucleus accumbens; ; cingulate gyrus; ; anterior cingulate cortex; ; Descending thoracic aorta; ; right frontal lobe;
	Top expressed in
	neural layer of retina; ; retinal pigment epithelium; ; epithelium of lens; ; pineal gland; ; corneal stroma; ; calvaria; ; interventricular septum; ; body of femur; ; muscle of thigh; ; myocardium of ventricle;
	More reference expression data
	More reference expression data
Orthologs
	6094
	19881
	ENSG00000149489
	ENSMUSG00000071648
	Q03395
	P32958
	NM_000327
	NM_009073
	NP_000318
	NP_033099
	Wikidata
View/Edit Human	View/Edit Mouse

Rod outer segment membrane protein 1 is a protein that in humans is encoded by the ROM1 gene.^[5]^[6]

This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor protein, peripherin-2 (PRPH2; retinal degeneration, slow; RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149489 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071648 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bascom RA, Schappert K, McInnes RR (Jul 1993). "Cloning of the human and murine ROM1 genes: genomic organization and sequence conservation". Hum Mol Genet. 2 (4): 385–391. doi:10.1093/hmg/2.4.385. PMID 8504299.
^ ^a ^b "Entrez Gene: ROM1 retinal outer segment membrane protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149489 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071648 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8504299-5] Bascom RA, Schappert K, McInnes RR (Jul 1993). "Cloning of the human and murine ROM1 genes: genomic organization and sequence conservation". Hum Mol Genet. 2 (4): 385–391. doi:10.1093/hmg/2.4.385. PMID 8504299.

[entrez-6] "Entrez Gene: ROM1 retinal outer segment membrane protein 1".

[1]

[2]

[3]

[4]

[5]

[6]