ROMK

KCNJ1
Identifiers
Aliases	KCNJ1, KIR1.1, ROMK, ROMK1, potassium voltage-gated channel subfamily J member 1, potassium inwardly rectifying channel subfamily J member 1
External IDs	OMIM: 600359; MGI: 1927248; HomoloGene: 56764; GeneCards: KCNJ1; OMA:KCNJ1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	128,867,373 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	32,310,493 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; kidney tubule; ; glomerulus; ; metanephric glomerulus; ; human kidney; ; testicle; ; nucleus accumbens; ; epithelium of colon; ; putamen; ; tail of epididymis;
	Top expressed in
	right kidney; ; human kidney; ; inner renal medulla; ; distal tubule; ; inner stripe of outer renal medulla; ; olfactory epithelium; ; connecting tubule; ; outer stripe of outer renal medulla; ; convoluted tubule; ; cortical collecting duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; voltage-gated ion channel activity; phosphatidylinositol-4,5-bisphosphate binding; inward rectifier potassium channel activity; ATP binding; ATP-activated inward rectifier potassium channel activity;
Cellular component	integral component of membrane; membrane; voltage-gated potassium channel complex; plasma membrane;
Biological process	excretion; regulation of ion transmembrane transport; ion transport; potassium ion transport; potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	3758
	56379
	ENSG00000151704
	ENSMUSG00000041248
	P48048
	O88335
	NM_153767; NM_000220; NM_153764; NM_153765; NM_153766
	NM_001168354; NM_019659
	NP_000211; NP_722448; NP_722449; NP_722450; NP_722451
	NP_001161826; NP_062633
	Wikidata
View/Edit Human	View/Edit Mouse

The renal outer medullary potassium channel (ROMK) is an ATP-dependent potassium channel (K_ir1.1) that transports potassium out of cells. It plays an important role in potassium recycling in the thick ascending limb (TAL) and potassium secretion in the cortical collecting duct (CCD) of the nephron. In humans, ROMK is encoded by the KCNJ1 (potassium inwardly-rectifying channel, subfamily J, member 1) gene.^[5]^[6]^[7] Multiple transcript variants encoding different isoforms have been found for this gene.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151704 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041248 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ho K, Nichols CG, Lederer WJ, Lytton J, Vassilev PM, Kanazirska MV, Hebert SC (March 1993). "Cloning and expression of an inwardly rectifying ATP-regulated potassium channel". Nature. 362 (6415): 31–8. Bibcode:1993Natur.362...31H. doi:10.1038/362031a0. PMID 7680431. S2CID 4332298.
^ Yano H, Philipson LH, Kugler JL, Tokuyama Y, Davis EM, Le Beau MM, Nelson DJ, Bell GI, Takeda J (May 1994). "Alternative splicing of human inwardly rectifying K+ channel ROMK1 mRNA". Molecular Pharmacology. 45 (5): 854–60. PMID 8190102.
^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151704 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041248 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7680431-5] Ho K, Nichols CG, Lederer WJ, Lytton J, Vassilev PM, Kanazirska MV, Hebert SC (March 1993). "Cloning and expression of an inwardly rectifying ATP-regulated potassium channel". Nature. 362 (6415): 31–8. Bibcode:1993Natur.362...31H. doi:10.1038/362031a0. PMID 7680431. S2CID 4332298.

[pmid8190102-6] Yano H, Philipson LH, Kugler JL, Tokuyama Y, Davis EM, Le Beau MM, Nelson DJ, Bell GI, Takeda J (May 1994). "Alternative splicing of human inwardly rectifying K+ channel ROMK1 mRNA". Molecular Pharmacology. 45 (5): 854–60. PMID 8190102.

[pmid16382105-7] Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.

[entrez-8] Cite error: The named reference entrez was invoked but never defined (see the help page).

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