Radixin

RDX
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRDX, DFNB24, radixin
External IDsOMIM: 179410; MGI: 97887; HomoloGene: 37707; GeneCards: RDX; OMA:RDX - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001104616
NM_001104617
NM_009041

RefSeq (protein)

NP_001098086
NP_001098087
NP_033067

Location (UCSC)Chr 11: 109.86 – 110.3 MbChr 9: 51.96 – 52.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Radixin is a protein that in humans is encoded by the RDX gene.[5][6][7]

Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137710Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032050Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wilgenbus KK, Milatovich A, Francke U, Furthmayr H (June 1993). "Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes". Genomics. 16 (1): 199–206. doi:10.1006/geno.1993.1159. PMID 8486357.
  6. ^ Khan SY, Ahmed ZM, Shabbir MI, Kitajiri S, Kalsoom S, Tasneem S, Shayiq S, Ramesh A, Srisailpathy S, Khan SN, Smith RJ, Riazuddin S, Friedman TB, Riazuddin S (April 2007). "Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus". Hum Mutat. 28 (5): 417–23. doi:10.1002/humu.20469. PMID 17226784. S2CID 7671031.
  7. ^ a b "Entrez Gene: RDX radixin".