Rama IV Road (Thai: ถนนพระรามที่ 4, RTGS: Thanon Phra Ram Thi Si; usually shortened to ถนนพระราม 4, RTGS: Thanon Phra Ram Si) is a main road in Bangkok, Thailand. It starts at Mo Mi Junction in the area of Bangkok's Chinatown in Samphanthawong and Pom Prap Sattru Phai Districts and ends at the junction with Sukhumvit Road (Phra Khanong Junction) in Khlong Toei District near Bangkok Port, also known as Khlong Toei Port.
Bordering the road are the Hua Lamphong railway station, Wat Hua Lamphong, New Sam Yan Market, Lumphini Park and Rama VI Memorial Plaza, King Chulalongkorn Memorial Hospital and Queen Saovabha Memorial Institute, the Metropolitan Electricity Authority, and the headquarters of Channel 3. The MRT Blue Line snakes underneath Rama IV Road between Hua Lamphong MRT station and Queen Sirikit National Convention Centre MRT station.