Receptor activity-modifying protein

Receptor activity-modifying protein
Identifiers
SymbolRAMP
PfamPF04901
InterProIPR006985
Membranome10
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Receptor activity-modifying protein 1
Identifiers
SymbolRAMP1
NCBI gene10267
HGNC9843
OMIM605153
RefSeqNM_005855
UniProtO60894
Other data
LocusChr. 2 q36-37.1
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StructuresSwiss-model
DomainsInterPro
Receptor activity-modifying protein 2
Identifiers
SymbolRAMP2
NCBI gene10266
HGNC9844
OMIM605154
RefSeqNM_005854
UniProtO60895
Other data
LocusChr. 17 q12-21.1
Search for
StructuresSwiss-model
DomainsInterPro
Receptor activity-modifying protein 3
Identifiers
SymbolRAMP3
NCBI gene10268
HGNC9845
OMIM605155
RefSeqNM_005856
UniProtO60896
Other data
LocusChr. 7 q13-p12
Search for
StructuresSwiss-model
DomainsInterPro

Receptor activity-modifying proteins (RAMPs) are a class of protein that interact with and modulate the activities of several Class B G protein-coupled receptors including the receptors for secretin, calcitonin (CT), glucagon, and vasoactive intestinal peptide (VIP).[1] There are three distinct types of RAMPs in mammals (though more in fish), designated RAMP1, RAMP2, and RAMP3, each encoded by a separate gene.[2]

  1. ^ Sexton PM, Morfis M, Tilakaratne N, Hay DL, Udawela M, Christopoulos G, Christopoulos A (2006). "Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs". Ann N Y Acad Sci. 1070 (1): 90–104. Bibcode:2006NYASA1070...90S. doi:10.1196/annals.1317.076. PMID 16888151. S2CID 83595488.
  2. ^ Young A (2005). "Receptor Pharmacology". Amylin: Physiology and Pharmacology; Chapter 3: Receptor pharmacology. Advances in Pharmacology. Vol. 52. pp. 47–65. doi:10.1016/S1054-3589(05)52003-9. ISBN 978-0-12-032954-0. PMID 16492540.