Protein-coding gene in the species Homo sapiens
Relaxin/insulin-like family peptide receptor 1 , also known as RXFP1 , is a human G protein coupled receptor that is one of the relaxin receptors .[ 5] It is a rhodopsin-like GPCR which is unusual in this class as it contains a large extracellular binding and signalling domain.[ 6] Some reports suggest that RXFP1 forms homodimers,[ 7] [ 8] however the most recent evidence indicates that relaxin binds a non-homodimer of RXFP1.[ 9] [ 10]
^ a b c GRCh38: Ensembl release 89: ENSG00000171509 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034009 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: RXFP1 relaxin/insulin-like family peptide receptor 1" .
^ Sethi A, Bruell S, Patil N, Hossain MA, Scott DJ, Petrie EJ, et al. (April 2016). "The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1" . Nature Communications . 7 (1): 11344. Bibcode :2016NatCo...711344S . doi :10.1038/ncomms11344 . PMC 4837482 . PMID 27088579 .
^ Svendsen AM, Zalesko A, Kønig J, Vrecl M, Heding A, Kristensen JB, et al. (December 2008). "Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1" (PDF) . Molecular and Cellular Endocrinology . 296 (1–2): 10–7. doi :10.1016/j.mce.2008.07.014 . PMID 18723073 . S2CID 32739782 .
^ Kern A, Hubbard D, Amano A, Bryant-Greenwood GD (March 2008). "Cloning, expression, and functional characterization of relaxin receptor (leucine-rich repeat-containing g protein-coupled receptor 7) splice variants from human fetal membranes" . Endocrinology . 149 (3): 1277–94. doi :10.1210/en.2007-1348 . PMC 2275365 . PMID 18079195 .
^ Hoare BL, Bruell S, Sethi A, Gooley PR, Lew MJ, Hossain MA, et al. (January 2019). "Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis" . iScience . 11 : 93–113. Bibcode :2019iSci...11...93H . doi :10.1016/j.isci.2018.12.004 . PMC 6309025 . PMID 30594862 .
^ Hoare BL, Kocan M, Bruell S, Scott DJ, Bathgate RA (August 2019). "Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis" . Pharmacology Research & Perspectives . 7 (4): e00513. doi :10.1002/prp2.513 . PMC 6667744 . PMID 31384473 .