Replication protein A3

RPA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1L1O, 1QUQ, 2PI2, 2PQA, 2Z6K, 3KDF
Identifiers
Aliases	RPA3, REPA3, RP-A p14, replication protein A3
External IDs	OMIM: 179837; MGI: 1915490; HomoloGene: 68285; GeneCards: RPA3; OMA:RPA3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	7,718,607 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	8,259,173 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; beta cell; ; trabecular bone; ; embryo; ; ventricular zone; ; bone marrow; ; olfactory zone of nasal mucosa; ; nasal epithelium; ; ganglionic eminence; ; mucosa of transverse colon;
	Top expressed in
	medial ganglionic eminence; ; otic placode; ; zygote; ; yolk sac; ; thymus; ; dermis; ; mandibular prominence; ; maxillary prominence; ; embryo; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	single-stranded DNA binding; DNA binding; damaged DNA binding; protein binding;
Cellular component	nucleus; nucleoplasm; DNA replication factor A complex; site of double-strand break;
Biological process	DNA recombination; translesion synthesis; DNA replication; nucleotide-excision repair, DNA gap filling; transcription-coupled nucleotide-excision repair; regulation of cell population proliferation; nucleotide-excision repair, DNA incision; error-free translesion synthesis; cellular response to DNA damage stimulus; regulation of mitotic cell cycle; regulation of cellular response to heat; interstrand cross-link repair; error-prone translesion synthesis; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex stabilization; nucleotide-excision repair; DNA repair; base-excision repair; double-strand break repair via homologous recombination; nucleotide-excision repair, preincision complex assembly; telomere maintenance; telomere maintenance via semi-conservative replication; G1/S transition of mitotic cell cycle; DNA mismatch repair; nucleotide-excision repair, DNA incision, 3'-to lesion; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	6119
	68240
	ENSG00000106399
	ENSMUSG00000012483
	P35244
	Q9CQ71
	NM_002947
	NM_026632
	NP_002938
	NP_080908
	Wikidata
View/Edit Human	View/Edit Mouse

Replication protein A 14 kDa subunit is a protein that in humans is encoded by the RPA3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106399 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000012483 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (Mar 1993). "Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A". The Journal of Biological Chemistry. 268 (9): 6131–8. doi:10.1016/S0021-9258(18)53229-4. PMID 8454588.
^ "Entrez Gene: RPA3 replication protein A3, 14kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106399 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000012483 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8454588-5] Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (Mar 1993). "Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A". The Journal of Biological Chemistry. 268 (9): 6131–8. doi:10.1016/S0021-9258(18)53229-4. PMID 8454588.

[entrez-6] "Entrez Gene: RPA3 replication protein A3, 14kDa".

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