Retinal G protein coupled receptor

RGR
Identifiers
Aliases	RGR, RP44, Retinal G protein coupled receptor
External IDs	OMIM: 600342; MGI: 1929473; HomoloGene: 37709; GeneCards: RGR; OMA:RGR - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	84,259,960 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	36,770,921 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; gastric mucosa; ; testicle; ; cingulate gyrus; ; anterior cingulate cortex; ; nucleus accumbens; ; caudate nucleus; ; right frontal lobe; ; gonad; ; Brodmann area 9;
	Top expressed in
	retinal pigment epithelium; ; choroid; ; olfactory epithelium; ; ciliary body; ; epithelium of lens; ; lacrimal gland; ; iris; ; neural layer of retina; ; corneal stroma; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; photoreceptor activity; signal transducer activity; G protein-coupled photoreceptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction; visual perception; response to stimulus; phototransduction; detection of visible light; cellular response to light stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5995
	57811
	ENSG00000148604
	ENSMUSG00000021804
	P47804
	Q9Z2B3
	NM_001012720; NM_001012722; NM_002921
	NM_001301692; NM_001301694; NM_021340
	NP_001012738; NP_001012740; NP_002912
	NP_001288621; NP_001288623; NP_067315
	Wikidata
View/Edit Human	View/Edit Mouse

RPE-retinal G protein-coupled receptor also known as RGR-opsin is a protein that in humans is encoded by the RGR gene.^[5]^[6] RGR-opsin is a member of the rhodopsin-like receptor subfamily of GPCR. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain.^[7]^[8] RGR-opsin comes in different isoforms produced by alternative splicing.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148604 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021804 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen XN, Korenberg JR, Jiang M, Shen D, Fong HK (June 1996). "Localization of the human RGR opsin gene to chromosome 10q23". Human Genetics. 97 (6): 720–722. doi:10.1007/BF02346179. PMID 8641686. S2CID 6086858.
^ ^a ^b "Entrez Gene: RGR retinal G protein coupled receptor".
^ Jiang M, Pandey S, Fong HK (December 1993). "An opsin homologue in the retina and pigment epithelium". Investigative Ophthalmology & Visual Science. 34 (13): 3669–3678. PMID 8258527.
^ Shen D, Jiang M, Hao W, Tao L, Salazar M, Fong HK (November 1994). "A human opsin-related gene that encodes a retinaldehyde-binding protein". Biochemistry. 33 (44): 13117–13125. doi:10.1021/bi00248a022. PMID 7947717.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148604 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021804 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8641686-5] Chen XN, Korenberg JR, Jiang M, Shen D, Fong HK (June 1996). "Localization of the human RGR opsin gene to chromosome 10q23". Human Genetics. 97 (6): 720–722. doi:10.1007/BF02346179. PMID 8641686. S2CID 6086858.

[entrez-6] "Entrez Gene: RGR retinal G protein coupled receptor".

[Jiang_1993-7] Jiang M, Pandey S, Fong HK (December 1993). "An opsin homologue in the retina and pigment epithelium". Investigative Ophthalmology & Visual Science. 34 (13): 3669–3678. PMID 8258527.

[Shen_1994-8] Shen D, Jiang M, Hao W, Tao L, Salazar M, Fong HK (November 1994). "A human opsin-related gene that encodes a retinaldehyde-binding protein". Biochemistry. 33 (44): 13117–13125. doi:10.1021/bi00248a022. PMID 7947717.

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