Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene.[5][6] Adapalene selectively targets retinoic acid receptor beta and retinoic acid receptor gamma[7] and its agonism of the gamma subtype is largely responsible for adapalene's observed effects.[8]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000172819 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001288 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: RARG retinoic acid receptor, gamma".
- ^ Lehmann JM, Hoffmann B, Pfahl M (Feb 1991). "Genomic organization of the retinoic acid receptor gamma gene". Nucleic Acids Research. 19 (3): 573–8. doi:10.1093/nar/19.3.573. PMC 333650. PMID 1849262.
- ^ Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G (2006). "Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety". Clinical Interventions in Aging. 1 (4): 327–48. doi:10.2147/ciia.2006.1.4.327. PMC 2699641. PMID 18046911.
- ^ Michel S, Jomard A, Démarchez M (October 1998). "Pharmacology of adapalene". The British Journal of Dermatology. 139 (Suppl 52): 3–7. doi:10.1046/j.1365-2133.1998.1390s2003.x. PMID 9990413. S2CID 23084886.