Retinoschisis

Retinoschisis
This condition is usually inherited in an X-linked recessive manner.
Specialty	Ophthalmology

Retinoschisis is an eye disease characterized by the abnormal splitting of the retina's neurosensory layers, usually in the outer plexiform layer. Retinoschisis can be divided into degenerative forms which are very common and almost exclusively involve the peripheral retina and hereditary forms which are rare and involve the central retina and sometimes the peripheral retina. The degenerative forms are asymptomatic and involve the peripheral retina only and do not affect the visual acuity. Some rarer forms result in a loss of vision in the corresponding visual field.^[1]

Almost all cases are X-linked recessive and caused by a mutation in the retinoschisin gene (RS1).^[2]