Rev-ErbA alpha

NR1D1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A6Y, 1GA5, 1HLZ, 3N00
Identifiers
Aliases	NR1D1, EAR1, THRA1, THRAL, ear-1, hRev, nuclear receptor subfamily 1 group D member 1, REVERBA, REVERBalpha
External IDs	OMIM: 602408; MGI: 2444210; HomoloGene: 23324; GeneCards: NR1D1; OMA:NR1D1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.1 Start 40,092,793 bp[1] End 40,100,589 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 98,658,758 bp[2] End 98,666,159 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen pancreatic ductal cell right lung ectocervix tibialis anterior muscle paraflocculus of cerebellum Brodmann area 10 right hemisphere of cerebellum nipple Top expressed in neural layer of retina lip ankle superior frontal gyrus esophagus aortic valve dentate gyrus of hippocampal formation granule cell primary visual cortex triceps brachii muscle ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity DNA-binding transcription factor activity zinc ion binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding steroid hormone receptor activity DNA-binding transcription repressor activity, RNA polymerase II-specific nuclear receptor activity core promoter sequence-specific DNA binding protein binding heme binding transcription corepressor binding DNA-binding transcription factor activity, RNA polymerase II-specific E-box binding transcription cis-regulatory region binding transcription factor binding nuclear receptor coactivator activity signaling receptor activity Cellular component cytoplasm cell projection dendritic spine nucleoplasm dendrite nucleus nuclear body RNA polymerase II transcription regulator complex Biological process cell differentiation regulation of insulin secretion involved in cellular response to glucose stimulus regulation of transcription, DNA-templated rhythmic process circadian temperature homeostasis positive regulation of bile acid biosynthetic process negative regulation of transcription by RNA polymerase II circadian regulation of gene expression regulation of fat cell differentiation transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of lipid metabolic process glycogen biosynthetic process regulation of circadian rhythm circadian rhythm proteasomal protein catabolic process transcription initiation from RNA polymerase II promoter response to leptin negative regulation of transcription, DNA-templated cellular response to lipopolysaccharide regulation of type B pancreatic cell proliferation negative regulation of toll-like receptor 4 signaling pathway steroid hormone mediated signaling pathway intracellular receptor signaling pathway cholesterol homeostasis multicellular organism development hormone-mediated signaling pathway response to lipid positive regulation of transcription by RNA polymerase II negative regulation of cold-induced thermogenesis protein destabilization regulation of circadian sleep/wake cycle negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of inflammatory response negative regulation of astrocyte activation cellular response to interleukin-1 cellular response to tumor necrosis factor negative regulation of neuroinflammatory response negative regulation of microglial cell activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9572 217166 Ensembl ENSG00000126368 ENSMUSG00000020889 UniProt P20393 Q3UV55 RefSeq (mRNA) NM_021724 NM_145434 RefSeq (protein) NP_068370 NP_663409 Location (UCSC) Chr 17: 40.09 – 40.1 Mb Chr 11: 98.66 – 98.67 Mb PubMed search [3] [4]
Wikidata
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Rev-Erb alpha (Rev-Erbɑ), also known as nuclear receptor subfamily 1 group D member 1 (NR1D1), is one of two Rev-Erb proteins in the nuclear receptor (NR) family of intracellular transcription factors. In humans, REV-ERBɑ is encoded by the NR1D1 gene, which is highly conserved across animal species.^[5]

Rev-Erbɑ plays an important role in regulation of the core circadian clock through repression of the positive clock element Bmal1. It also regulates several physiological processes under circadian control, including metabolic and immune pathways.^[6][7] Rev-Erbɑ mRNA demonstrates circadian oscillation in its expression, and it is highly expressed in mammals in the brain and metabolic tissues such as skeletal muscle, adipose tissue, and liver.^[6][8]