Rev-ErbA beta

NR1D2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4N73, 2V0V, 2V7C, 3CQV
Identifiers
Aliases	NR1D2, BD73, EAR-1R, RVR, nuclear receptor subfamily 1 group D member 2, REVERBB, REVERBbeta
External IDs	OMIM: 602304; MGI: 2449205; HomoloGene: 3763; GeneCards: NR1D2; OMA:NR1D2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p24.2 Start 23,945,286 bp[1] End 23,980,617 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A2 Start 18,204,054 bp[2] End 18,239,127 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon biceps brachii Skeletal muscle tissue of biceps brachii caput epididymis Skeletal muscle tissue of rectus abdominis tail of epididymis parietal pleura superficial temporal artery corpus epididymis retinal pigment epithelium Top expressed in cerebellar vermis lobe of cerebellum iris Epithelium of choroid plexus medial geniculate nucleus median eminence habenula medial dorsal nucleus skin of external ear lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity zinc ion binding metal ion binding steroid hormone receptor activity nuclear receptor activity core promoter sequence-specific DNA binding protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor binding nuclear receptor coactivator activity signaling receptor activity Cellular component nucleus nucleoplasm RNA polymerase II transcription regulator complex cytoplasm Biological process regulation of transcription, DNA-templated regulation of skeletal muscle cell differentiation rhythmic process transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of lipid metabolic process regulation of circadian rhythm regulation of inflammatory response lipid homeostasis transcription initiation from RNA polymerase II promoter negative regulation of transcription, DNA-templated steroid hormone mediated signaling pathway intracellular receptor signaling pathway negative regulation of transcription by RNA polymerase II energy homeostasis multicellular organism development hormone-mediated signaling pathway cell differentiation response to lipid positive regulation of transcription by RNA polymerase II circadian behavior negative regulation of inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9975 353187 Ensembl ENSG00000174738 ENSMUSG00000021775 UniProt Q14995 Q6NSM0 Q60674 RefSeq (mRNA) NM_001145425 NM_005126 NM_011584 RefSeq (protein) NP_001138897 NP_005117 NP_035714 Location (UCSC) Chr 3: 23.95 – 23.98 Mb Chr 14: 18.2 – 18.24 Mb PubMed search [3] [4]
Wikidata
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Rev-Erb beta (Rev-Erbβ), also known as nuclear receptor subfamily 1 group D member 2 (NR1D2), is a member of the Rev-Erb protein family. Rev-Erbβ, like Rev-Erbα, belongs to the nuclear receptor superfamily of transcription factors and can modulate gene expression through binding to gene promoters.^[5] Together with Rev-Erbα, Rev-Erbβ functions as a major regulator of the circadian clock. These two proteins are partially redundant.^[6] Current research suggests that Rev-Erbβ is less important in maintaining the circadian clock than Rev-Erbα; knock-out studies of Rev-Erbα result in significant circadian disruption but the same has not been found with Rev-Erbβ. Rev-Erbβ compensation for Rev-Erbα varies across tissues, and further research is needed to elucidate the separate role of Rev-Erbβ.^[7]

This gene is expressed in the central and peripheral nervous system, spleen, mandibular maxillary processes, and blood islands. Rev-Erbβ plays a major role in the conduction of inductive signals to aid in controlling differentiating neurons.^[5]