RhoC

RHOC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z2C, 2GCN, 2GCO, 2GCP
Identifiers
Aliases	RHOC, ARH9, ARHC, H9, RHOH9, RhoC, ras homolog family member C
External IDs	OMIM: 165380; MGI: 106028; HomoloGene: 90945; GeneCards: RHOC; OMA:RHOC - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	112,707,434 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	104,701,775 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; stromal cell of endometrium; ; ascending aorta; ; apex of heart; ; Descending thoracic aorta; ; tibial nerve; ; right coronary artery; ; myometrium; ; smooth muscle tissue; ; left coronary artery;
	Top expressed in
	decidua; ; gastrula; ; left colon; ; yolk sac; ; ascending aorta; ; aortic valve; ; duodenum; ; ankle joint; ; lacrimal gland; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; signal transducer activity; GTPase activity;
Cellular component	cytosol; plasma membrane; cleavage furrow; extracellular exosome; membrane; nucleus; intracellular anatomical structure; stereocilium;
Biological process	positive regulation of I-kappaB kinase/NF-kappaB signaling; skeletal muscle satellite cell migration; regulation of small GTPase mediated signal transduction; apical junction assembly; wound healing, spreading of cells; positive regulation of lipase activity; small GTPase mediated signal transduction; positive regulation of protein homooligomerization; mitotic cytokinesis; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	389
	11853
	ENSG00000155366
	ENSMUSG00000002233
	P08134; Q5JR06
	Q62159
	NM_175744; NM_001042678; NM_001042679
	NM_001291859; NM_007484
	NP_001036143; NP_001036144; NP_786886
	NP_001278788; NP_031510
	Wikidata
View/Edit Human	View/Edit Mouse

RhoC (Ras homolog gene family, member C) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.^[5] It is encoded by the gene RHOC.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155366 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002233 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.
^ "Entrez Gene: RHOC ras homolog gene family, member C".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155366 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002233 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Ridley-5] Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.

[entrezc-6] "Entrez Gene: RHOC ras homolog gene family, member C".

[1]

[2]

[3]

[4]

[5]

[6]