Riluzole

Riluzole
Clinical data
Trade namesRilutek, Tiglutik, Exservan, others
AHFS/Drugs.comMonograph
MedlinePlusa696013
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability60±18%[4]
Protein binding97%[4]
MetabolismHepatic (CYP1A2)[4]
Elimination half-life9–15 hours[4]
ExcretionUrine (90%)[4]
Identifiers
  • 6-(trifluoromethoxy)benzothiazol-2-amine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.124.754 Edit this at Wikidata
Chemical and physical data
FormulaC8H5F3N2OS
Molar mass234.20 g·mol−1
3D model (JSmol)
  • FC(F)(F)Oc1ccc2nc(sc2c1)N
  • InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13) checkY
  • Key:FTALBRSUTCGOEG-UHFFFAOYSA-N checkY
  (verify)

Riluzole is a medication used to treat amyotrophic lateral sclerosis and other motor neuron diseases. Riluzole delays the onset of ventilator-dependence or tracheostomy in some people and may increase survival by two to three months.[5] Riluzole is available in tablet and liquid form.

  1. ^ "Rilutek (riluzole) tablets, for oral useInitial U.S. Approval: 1995". DailyMed. Retrieved August 26, 2024.
  2. ^ https://www.accessdata.fda.gov/drugsatfda_docs/nda/pre96/020599Orig1s000rev.pdf [bare URL PDF]
  3. ^ Cite error: The named reference Rilutek EPAR was invoked but never defined (see the help page).
  4. ^ a b c d e "PRODUCT INFORMATION RILUTEK® (riluzole) Tablets" (PDF). TGA eBusiness Services. sanofi-aventis australia pty ltd. January 6, 2009. Retrieved February 18, 2014.
  5. ^ Miller RG, Mitchell JD, Moore DH (March 2012). "Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)". The Cochrane Database of Systematic Reviews. 2012 (3): CD001447. doi:10.1002/14651858.CD001447.pub3. PMC 7055506. PMID 22419278.