Rimegepant

Rimegepant
Clinical data
Trade namesNurtec ODT, Vydura
Other namesBHV-3000, BMS-927711
AHFS/Drugs.comMonograph
MedlinePlusa620031
License data
Pregnancy
category
Routes of
administration		By mouth
Drug classCalcitonin gene-related peptide receptor antagonist
ATC code
Legal status
Legal status
Identifiers
  • [(5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl] 4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC28H28F2N6O3
Molar mass534.568 g·mol−1
3D model (JSmol)
  • N[C@@H]1c2cccnc2[C@H](OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)CC[C@H]1c1cccc(F)c1F
  • InChI=1S/C28H28F2N6O3/c29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37/h1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37)/t18-,22+,24-/m0/s1
  • Key:KRNAOFGYEFKHPB-ANJVHQHFSA-N

Rimegepant, sold under the brand name Nurtec ODT among others, is a medication used for the acute treatment of migraine with or without aura in adults and the prophylactic/ preventive treatment of episodic migraine in adults.[8][10] It is taken by mouth to dissolve on or under the tongue.[8] It works by blocking CGRP receptors.[11]

In the United States, rimegepant was approved for treating acute migraine in February 2020,[12] and its approval was extended to preventing episodic migraine in June 2021.[8] It is produced and marketed by Pfizer.[13] In March 2021, rimegepant was approved for medical use in the United Arab Emirates and in Israel.[14][15] It was approved for medical use in Canada in December 2023.[4] In the United Kingdom, rimegepant is approved by NICE for the prophylaxis and treatment of acute migraine in adults.[16]

  1. ^ a b "Nurtec ODT". Therapeutic Goods Administration (TGA). 8 August 2023. Archived from the original on 11 October 2023. Retrieved 10 September 2023.
  2. ^ https://www.tga.gov.au/resources/auspar/auspar-nurtec-odt [bare URL]
  3. ^ "Nurtec ODT (Pfizer Australia Pty Ltd)". Therapeutic Goods Administration (TGA). 22 August 2023. Archived from the original on 11 September 2023. Retrieved 10 September 2023.
  4. ^ a b "Archived copy" (PDF). Archived (PDF) from the original on 3 March 2024. Retrieved 10 March 2024.{{cite web}}: CS1 maint: archived copy as title (link)
  5. ^ "Notice: Multiple additions to the Prescription Drug List (PDL) [2024-02-28]". Health Canada. 28 February 2024. Archived from the original on 2 March 2024. Retrieved 2 March 2024.
  6. ^ "Details for: Nurtec ODT". Health Canada. 1 December 2023. Archived from the original on 3 March 2024. Retrieved 3 March 2024.
  7. ^ "Summary Basis of Decision for Nurtec ODT". Drug and Health Products Portal. 1 September 2012. Retrieved 23 July 2024.
  8. ^ a b c d "Nurtec ODT - rimegepant sulfate tablet, orally disintegrating". DailyMed. 19 February 2020. Archived from the original on 28 November 2020. Retrieved 19 March 2020.
  9. ^ "Vydura EPAR". European Medicines Agency (EMA). 22 February 2022. Archived from the original on 16 October 2022. Retrieved 11 May 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  10. ^ "Drug Trials Snapshots: Nurtec ODT". U.S. Food and Drug Administration (FDA). 27 February 2020. Archived from the original on 1 October 2020. Retrieved 19 March 2020. Public Domain This article incorporates text from this source, which is in the public domain.
  11. ^ Cite error: The named reference pmid 26376968 was invoked but never defined (see the help page).
  12. ^ "Drug Approval Package: Nurtec ODT". U.S. Food and Drug Administration (FDA). 26 March 2020. Archived from the original on 27 December 2021. Retrieved 16 October 2022.
  13. ^ "Pfizer Completes Acquisition of Biohaven Pharmaceuticals". Pfizer (Press release). 3 October 2022. Archived from the original on 5 October 2022. Retrieved 16 October 2022.
  14. ^ "Biohaven Pharma's Nurtec ODT Approved In Israel For Acute Treatment Of Migraine". StreetInsider.com. Archived from the original on 3 June 2021. Retrieved 3 June 2021.
  15. ^ "Biohaven's Nurtec ODT Approved In United Arab Emirates For Acute Treatment Of Migraine". Biohaven Pharmaceuticals (Press release). Archived from the original on 11 March 2021. Retrieved 3 June 2021.
  16. ^ "Overview | Rimegepant for treating migraine | Guidance | NICE". www.nice.org.uk. 18 October 2023. Retrieved 26 July 2024.