Common side effects of ritonavir include nausea, vomiting, loss of appetite, diarrhea, and numbness of the hands and feet.[8] Serious side effects include liver complications, pancreatitis, allergic reactions, and arrhythmias.[8] Serious interactions may occur with a number of other medications including amiodarone and simvastatin.[8] At low doses, it is considered to be acceptable for use during pregnancy.[12] Ritonavir is of the protease inhibitor class.[8] However, it is also commonly used to inhibit the enzyme that metabolizes other protease inhibitors.[13] This inhibition allows lower doses of these latter medications to be used.[13]
^Danner SA, Carr A, Leonard JM, Lehman LM, Gudiol F, Gonzales J, Raventos A, Rubio R, Bouza E, Pintado V, Aguado AG, Garcia de Lomas J, Delgado R, Borleffs JC, Hsu A, Valdes JM, Boucher CA, Cooper DA (December 1995). "A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease. European-Australian Collaborative Ritonavir Study Group". The New England Journal of Medicine. 333 (23): 1528–1533. doi:10.1056/NEJM199512073332303. hdl:2445/121979. PMID7477167.
^ abcdefgh"Ritonavir". The American Society of Health-System Pharmacists. Archived from the original on October 17, 2015. Retrieved October 23, 2015.
^Talha B, Dhamoon AS (August 8, 2023). "Ritonavir". StatPearls. StatPearls Publishing. PMID31335032. Retrieved January 6, 2024.
^Cite error: The named reference FDA-ucm427530 was invoked but never defined (see the help page).
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.