Roxarsone

Roxarsone
Skeletal formula of roxarsone
Space-filling model of the roxarsone molecule
Names
Preferred IUPAC name
(4-Hydroxy-3-nitrophenyl)arsonic acid
Identifiers
3D model (JSmol)
1976533
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.004.049 Edit this at Wikidata
EC Number
  • 204-453-7
1221211
KEGG
MeSH Roxarsone
RTECS number
  • CY5250000
UNII
UN number 3465
  • InChI=1S/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12) checkY
    Key: XMVJITFPVVRMHC-UHFFFAOYSA-N checkY
  • InChI=1/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12)
    Key: XMVJITFPVVRMHC-UHFFFAOYAF
  • Oc1ccc(cc1[N+](=O)[O-])[As](O)(O)=O
  • OC1=CC=C(C=C1[N+]([O-])=O)[As](O)(O)=O
Properties
C
6AsNH
6O
6
Molar mass 263.0365 g mol−1
Melting point > 300 °C (572 °F; 573 K)
Hazards
GHS labelling:
GHS06: Toxic GHS09: Environmental hazard
Danger
H301, H331, H410
P261, P273, P301+P310, P311, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Roxarsone is an organoarsenic compound that has been used in poultry production as a feed additive to increase weight gain and improve feed efficiency, and as a coccidiostat.[1] As of June 2011, it was approved for chicken feed in the United States, Canada, Australia, and 12 other countries.[2] The drug was also approved in the United States and elsewhere for use in pigs.[1][2]

Its use in the United States was voluntarily ended by the manufacturers in June 2011 and has been illegal since 2013.[3][4] Its use was immediately suspended in Malaysia.[5] It was banned in Canada in August 2011.[6] In Australia, its use in chicken feed was discontinued in 2012.[7] Roxarsone has been banned in the European Union since 1999.[8]

  1. ^ a b U.S. Food and Drug Administration (June 8, 2011). "Questions and Answers Regarding 3-Nitro (Roxarsone)".
  2. ^ a b Harris, Gardiner; Grady, Denise (9 June 2011). "Pfizer Suspends Sales of Chicken Drug". The New York Times. Retrieved 19 October 2018.
  3. ^ Cite error: The named reference withdrawn was invoked but never defined (see the help page).
  4. ^ "Arsenic in Chicken: Does chicken meat contain arsenic?". Chicken Check In. 21 July 2017. Retrieved 20 March 2018.
  5. ^ "Malaysian Pharmaceutical Society". Malaysian Pharmaceutical Society. Retrieved 19 October 2018.
  6. ^ "Sales halted after arsenic found in chicken drug". The Globe and Mail. 3 May 2018. Retrieved 19 October 2018.
  7. ^ "Roxarsone not used in the Australian chicken industry" (PDF). Australian Meat Chicken Federation. 24 May 2018. Retrieved 19 October 2018.
  8. ^ Philpott, Tom (11 June 2011). "Some Arsenic With That Supermarket Chicken?". Mother Jones. Retrieved 19 October 2018.