Ruben is the surname of:
- Aaron Ruben (1914–2010), American television director and producer
- Adam Ruben, American writer, comedian, rapper, storyteller, science communicator and molecular biologist
- Alessandro Ruben (born 1966), Italian politician
- Carlos Rubén (born 1983), Spanish footballer
- J. Walter Ruben (1899–1942), American screenwriter, film director and producer
- Joseph Ruben (born 1950), American retired filmmaker
- Josh Ruben (born 1983), American actor, comedian, film director and producer
- Livingston Antony Ruben, aka Ruben (film editor), Indian film editor
- Marco Ruben (born 1986), Argentine former footballer
- Sam Ruben (1913–1943), American chemist
- Samuel Ruben (1900–1988), American inventor
- Walter Ruben (Indologist) (1899–1982), German Indologist