S. Rajendran may refer to:
- S. Rajendran (AIADMK politician) (1956–2019), Indian politician and Member of Parliament elected from Viluppuram (Lok Sabha constituency) Tamil Nadu
- S. Rajendran, AIADMK politician and MLA in the period 2016-2021 from Ariyalur
- S. Rajendran (CPI politician) Indian politician and former Member of the Legislative Assembly of Tamil Nadu from Kovilpatti (state assembly constituency)
- S. Rajendran (CPI(M) politician), Indian politician and former Member of the Legislative Assembly of Kerala
- S. S. Rajendran, Indian actor, director, producer and politician
- S. N. Rajendran
- S. K. Rajendran
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