S100B

S100B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MQ1, 1UWO, 2H61, 2M49, 2PRU, 3CZT, 3D0Y, 3D10, 3HCM, 4XYN, 5CSJ, 5CSF, 5CSN, 5CSI
Identifiers
Aliases	S100B, NEF, S100, S100-B, S100beta, S100 calcium binding protein B
External IDs	OMIM: 176990; MGI: 98217; HomoloGene: 4567; GeneCards: S100B; OMA:S100B - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 46,598,604 bp[1] End 46,605,208 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 38.76 cM Start 76,089,687 bp[2] End 76,096,993 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment inferior ganglion of vagus nerve olfactory bulb subthalamic nucleus trigeminal ganglion internal globus pallidus medulla oblongata superior vestibular nucleus substantia nigra pars reticulata Top expressed in vestibular membrane of cochlear duct lobe of cerebellum anterior horn of spinal cord cerebellar vermis deep cerebellar nuclei stria vascularis pontine nuclei facial motor nucleus optic nerve utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding S100 protein binding protein homodimerization activity zinc ion binding metal ion binding calcium-dependent protein binding protein binding identical protein binding tau protein binding signaling receptor binding RAGE receptor binding Cellular component cytoplasm ruffle extracellular region soma perinuclear region of cytoplasm nucleus extracellular space Biological process axonogenesis response to glucocorticoid memory negative regulation of skeletal muscle cell differentiation central nervous system development astrocyte differentiation positive regulation of synaptic transmission positive regulation of cell population proliferation regulation of cell shape positive regulation of apoptotic process learning or memory positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of neuronal synaptic plasticity response to methylmercury cell population proliferation innate immune response cellular response to hypoxia long-term potentiation positive regulation of myelination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6285 20203 Ensembl ENSG00000160307 ENSMUSG00000033208 UniProt P04271 P50114 RefSeq (mRNA) NM_006272 NM_009115 RefSeq (protein) NP_006263 NP_033141 Location (UCSC) Chr 21: 46.6 – 46.61 Mb Chr 10: 76.09 – 76.1 Mb PubMed search [3] [4]
Wikidata
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S100 calcium-binding protein B (S100B) is a protein of the S100 protein family.

S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3.