S1PR1

S1PR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3V2W, 3V2Y
Identifiers
Aliases	S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1
External IDs	OMIM: 601974; MGI: 1096355; HomoloGene: 1071; GeneCards: S1PR1; OMA:S1PR1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	101,243,713 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	115,508,721 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; ventricular zone; ; granulocyte; ; subcutaneous adipose tissue; ; apex of heart; ; left ventricle; ; right auricle; ; caudate nucleus; ; right lobe of thyroid gland;
	Top expressed in
	right lung lobe; ; globus pallidus; ; dentate gyrus of hippocampal formation granule cell; ; atrium; ; left lung; ; superior frontal gyrus; ; inferior colliculi; ; mesenteric lymph nodes; ; cerebellar cortex; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sphingolipid binding; sphingosine-1-phosphate receptor activity; G protein-coupled receptor activity; signal transducer activity; G protein-coupled receptor binding; protein binding;
Cellular component	integral component of membrane; endosome; membrane; intrinsic component of plasma membrane; plasma membrane; membrane raft; external side of plasma membrane; nucleoplasm; intracellular membrane-bounded organelle;
Biological process	actin cytoskeleton reorganization; T cell migration; G protein-coupled receptor signaling pathway; heart trabecula morphogenesis; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; sphingosine-1-phosphate receptor signaling pathway; positive regulation of cell migration; regulation of bone mineralization; transmission of nerve impulse; chemotaxis; positive regulation of positive chemotaxis; positive regulation of GTPase activity; brain development; regulation of cell adhesion; cell adhesion; angiogenesis; neuron differentiation; positive regulation of cell population proliferation; endothelial cell differentiation; negative regulation of stress fiber assembly; regulation of bone resorption; cell migration; signal transduction; lamellipodium assembly; positive regulation of transcription by RNA polymerase II; cardiac muscle tissue growth involved in heart morphogenesis; positive regulation of smooth muscle cell proliferation; blood vessel maturation; leukocyte chemotaxis; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1901
	13609
	ENSG00000170989
	ENSMUSG00000045092
	P21453
	O08530
	NM_001400; NM_001320730
	NM_007901
	NP_001307659; NP_001391
	NP_031927
	Wikidata
View/Edit Human	View/Edit Mouse

Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5).^[5] S1PR1 was originally identified as an abundant transcript in endothelial cells^[6] and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation.^[7]^[8] In addition, S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking.^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170989 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045092 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference Hanson_2012 was invoked but never defined (see the help page).
^ Hla T, Maciag T (June 1990). "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors". The Journal of Biological Chemistry. 265 (16): 9308–9313. doi:10.1016/S0021-9258(19)38849-0. PMID 2160972.
^ Lee MJ, Van Brocklyn JR, Thangada S, Liu CH, Hand AR, Menzeleev R, et al. (March 1998). "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1". Science. 279 (5356): 1552–1555. Bibcode:1998Sci...279.1552L. doi:10.1126/science.279.5356.1552. PMID 9488656.
^ Liu CH, Thangada S, Lee MJ, Van Brocklyn JR, Spiegel S, Hla T (April 1999). "Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1". Molecular Biology of the Cell. 10 (4): 1179–1190. doi:10.1091/mbc.10.4.1179. PMC 25247. PMID 10198065.
^ Allende ML, Dreier JL, Mandala S, Proia RL (April 2004). "Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration". The Journal of Biological Chemistry. 279 (15): 15396–15401. doi:10.1074/jbc.M314291200. PMID 14732704.
^ Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, et al. (January 2004). "Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1". Nature. 427 (6972): 355–360. Bibcode:2004Natur.427..355M. doi:10.1038/nature02284. PMID 14737169. S2CID 4371877.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170989 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045092 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Hanson_2012-5] Cite error: The named reference Hanson_2012 was invoked but never defined (see the help page).

[Hla_1990-6] Hla T, Maciag T (June 1990). "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors". The Journal of Biological Chemistry. 265 (16): 9308–9313. doi:10.1016/S0021-9258(19)38849-0. PMID 2160972.

[Lee_1998-7] Lee MJ, Van Brocklyn JR, Thangada S, Liu CH, Hand AR, Menzeleev R, et al. (March 1998). "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1". Science. 279 (5356): 1552–1555. Bibcode:1998Sci...279.1552L. doi:10.1126/science.279.5356.1552. PMID 9488656.

[Liu_1999-8] Liu CH, Thangada S, Lee MJ, Van Brocklyn JR, Spiegel S, Hla T (April 1999). "Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1". Molecular Biology of the Cell. 10 (4): 1179–1190. doi:10.1091/mbc.10.4.1179. PMC 25247. PMID 10198065.

[Allende_2004-9] Allende ML, Dreier JL, Mandala S, Proia RL (April 2004). "Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration". The Journal of Biological Chemistry. 279 (15): 15396–15401. doi:10.1074/jbc.M314291200. PMID 14732704.

[Matloubian_2004-10] Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, et al. (January 2004). "Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1". Nature. 427 (6972): 355–360. Bibcode:2004Natur.427..355M. doi:10.1038/nature02284. PMID 14737169. S2CID 4371877.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]