SALL4

SALL4
Identifiers
AliasesSALL4, DRRS, HSAL4, ZNF797, dJ1112F19.1, spalt-like transcription factor 4, spalt like transcription factor 4, IVIC
External IDsOMIM: 607343; MGI: 2139360; HomoloGene: 10716; GeneCards: SALL4; OMA:SALL4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

57167

99377

Ensembl

ENSG00000101115

ENSMUSG00000027547

UniProt

Q9UJQ4
Q6Y8G5

Q8BX22

RefSeq (mRNA)

NM_020436
NM_001318031

NM_175303
NM_201395
NM_201396

RefSeq (protein)

NP_001304960
NP_065169

NP_780512
NP_958797
NP_958798

Location (UCSC)Chr 20: 51.78 – 51.8 MbChr 2: 168.59 – 168.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sal-like protein 4 (SALL4) is a transcription factor encoded by a member of the Spalt-like (SALL) gene family, SALL4.[5][6] The SALL genes were identified based on their sequence homology to Spalt, which is a homeotic gene originally cloned in Drosophila melanogaster that is important for terminal trunk structure formation in embryogenesis and imaginal disc development in the larval stages.[7][8] There are four human SALL proteins (SALL1, 2, 3, and 4) with structural homology and playing diverse roles in embryonic development, kidney function, and cancer.[9] The SALL4 gene encodes at least three isoforms, termed A, B, and C, through alternative splicing, with the A and B forms being the most studied. SALL4 can alter gene expression changes through its interaction with many co-factors and epigenetic complexes.[10] It is also known as a key embryonic stem cell (ESC) factor.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101115 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027547 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SALL4 sal-like 4 (Drosophila)".
  6. ^ Tatetsu H, Kong NR, Chong G, Amabile G, Tenen DG, Chai L (June 2016). "SALL4, the missing link between stem cells, development and cancer". Gene. 584 (2): 111–119. doi:10.1016/j.gene.2016.02.019. PMC 4823161. PMID 26892498.
  7. ^ Kühnlein RP, Frommer G, Friedrich M, Gonzalez-Gaitan M, Weber A, Wagner-Bernholz JF, Gehring WJ, Jäckle H, Schuh R (Jan 1994). "spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo". The EMBO Journal. 13 (1): 168–179. doi:10.1002/j.1460-2075.1994.tb06246.x. PMC 394790. PMID 7905822.
  8. ^ Kühnlein RP, Brönner G, Taubert H, Schuh R (Aug 1997). "Regulation of Drosophila spalt gene expression". Mechanisms of Development. 66 (1–2): 107–118. doi:10.1016/s0925-4773(97)00103-2. hdl:11858/00-001M-0000-0012-FF2D-C. PMID 9376314. S2CID 6371456.
  9. ^ de Celis JF, Barrio R (2009). "Regulation and function of Spalt proteins during animal development". The International Journal of Developmental Biology. 53 (8–10): 1385–1398. doi:10.1387/ijdb.072408jd. hdl:10261/37592. PMID 19247946.
  10. ^ Kohlhase J, Chitayat D, Kotzot D, Ceylaner S, Froster UG, Fuchs S, Montgomery T, Rösler B (Sep 2005). "SALL4 mutations in Okihiro syndrome (Duane-radial ray syndrome), acro-renal-ocular syndrome, and related disorders". Human Mutation. 26 (3): 176–183. doi:10.1002/humu.20215. PMID 16086360. S2CID 32696827.