SATB1

SATB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YSE, 2L1P, 2O49, 2O4A, 3NZL, 3TUO, 2MW8
Identifiers
Aliases	SATB1, SATB homeobox 1, DEFDA, KTZSL
External IDs	OMIM: 602075; MGI: 105084; HomoloGene: 2232; GeneCards: SATB1; OMA:SATB1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	18,445,588 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	52,140,318 bp
RNA expression pattern
	Top expressed in
	orbitofrontal cortex; ; frontal pole; ; thymus; ; Brodmann area 46; ; parietal lobe; ; postcentral gyrus; ; parotid gland; ; Brodmann area 10; ; entorhinal cortex; ; Brodmann area 23;
	Top expressed in
	thymus; ; molar; ; barrel cortex; ; zygote; ; secondary oocyte; ; Rostral migratory stream; ; substantia nigra; ; lacrimal gland; ; vastus lateralis muscle; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; chromatin binding; protein binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding;
Cellular component	PML body; nuclear matrix; nucleoplasm; chromatin; nucleus; nuclear body;
Biological process	reflex; CD4-positive, alpha-beta T cell differentiation; CD8-positive, alpha-beta T cell differentiation; chromatin remodeling; activated T cell proliferation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; chromatin organization; transcription, DNA-templated; epidermis development; histone methylation; viral process; T cell activation;
	Sources:Amigo / QuickGO
Orthologs
	6304
	20230
	ENSG00000182568
	ENSMUSG00000023927
	Q01826
	Q60611
NM_001131010; NM_001195470; NM_002971; NM_001322871; NM_001322872;
	NM_001322873; NM_001322874; NM_001322875; NM_001322876
NM_001163630; NM_001163631; NM_001163632; NM_009122; NM_001357636;
	NM_001357637; NM_001357638; NM_001357640
NP_001124482; NP_001182399; NP_001309800; NP_001309801; NP_001309802;
	NP_001309803; NP_001309804; NP_001309805; NP_002962
NP_001157102; NP_001157103; NP_001157104; NP_033148; NP_001344565;
	NP_001344566; NP_001344567; NP_001344569
	Wikidata
View/Edit Human	View/Edit Mouse

SATB1 (special AT-rich sequence-binding protein-1) is a protein which in humans is encoded by the SATB1 gene.^[5] It is a dimeric/tetrameric transcription factor^[6] with multiple DNA binding domains (CUT1, CUT2 and a Homeobox domain). SATB1 specifically binds to AT-rich DNA sequences with high unwinding propensity^[7] called base unpairing regions (BURs), containing matrix attachment regions (MARs).^[8]^[9]^[10]^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182568 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023927 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SATB1 SATB homeobox 1".
^ Nakagomi K, Kohwi Y, Dickinson LA, Kohwi-Shigematsu T (March 1994). "A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1". Molecular and Cellular Biology. 14 (3): 1852–1860. doi:10.1128/MCB.14.3.1852. PMC 358543. PMID 8114718.
^ Bode J, Kohwi Y, Dickinson L, Joh T, Klehr D, Mielke C, Kohwi-Shigematsu T (January 1992). "Biological significance of unwinding capability of nuclear matrix-associating DNAs". Science. 255 (5041): 195–197. Bibcode:1992Sci...255..195B. doi:10.1126/science.1553545. PMID 1553545.
^ Dickinson LA, Joh T, Kohwi Y, Kohwi-Shigematsu T (August 1992). "A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition". Cell. 70 (4): 631–645. doi:10.1016/0092-8674(92)90432-c. PMID 1505028. S2CID 41115832.
^ Cite error: The named reference Dickinson_1997 was invoked but never defined (see the help page).
^ Yamasaki K, Akiba T, Yamasaki T, Harata K (2007-07-25). "Structural basis for recognition of the matrix attachment region of DNA by transcription factor SATB1". Nucleic Acids Research. 35 (15): 5073–5084. doi:10.1093/nar/gkm504. PMC 1976457. PMID 17652321.
^ Ghosh RP, Shi Q, Yang L, Reddick MP, Nikitina T, Zhurkin VB, et al. (July 2019). "Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions". Nature Communications. 10 (1): 3221. Bibcode:2019NatCo..10.3221G. doi:10.1038/s41467-019-11118-8. PMC 6642133. PMID 31324780.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182568 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023927 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SATB1 SATB homeobox 1".

[6] Nakagomi K, Kohwi Y, Dickinson LA, Kohwi-Shigematsu T (March 1994). "A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1". Molecular and Cellular Biology. 14 (3): 1852–1860. doi:10.1128/MCB.14.3.1852. PMC 358543. PMID 8114718.

[7] Bode J, Kohwi Y, Dickinson L, Joh T, Klehr D, Mielke C, Kohwi-Shigematsu T (January 1992). "Biological significance of unwinding capability of nuclear matrix-associating DNAs". Science. 255 (5041): 195–197. Bibcode:1992Sci...255..195B. doi:10.1126/science.1553545. PMID 1553545.

[8] Dickinson LA, Joh T, Kohwi Y, Kohwi-Shigematsu T (August 1992). "A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition". Cell. 70 (4): 631–645. doi:10.1016/0092-8674(92)90432-c. PMID 1505028. S2CID 41115832.

[Dickinson_1997-9] Cite error: The named reference Dickinson_1997 was invoked but never defined (see the help page).

[Yamasaki_2007-10] Yamasaki K, Akiba T, Yamasaki T, Harata K (2007-07-25). "Structural basis for recognition of the matrix attachment region of DNA by transcription factor SATB1". Nucleic Acids Research. 35 (15): 5073–5084. doi:10.1093/nar/gkm504. PMC 1976457. PMID 17652321.

[Ghosh_2019-11] Ghosh RP, Shi Q, Yang L, Reddick MP, Nikitina T, Zhurkin VB, et al. (July 2019). "Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions". Nature Communications. 10 (1): 3221. Bibcode:2019NatCo..10.3221G. doi:10.1038/s41467-019-11118-8. PMC 6642133. PMID 31324780.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]