SCN8A

SCN8A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WFN
Identifiers
Aliases	SCN8A, CERIII, CIAT, EIEE13, MED, NaCh6, Nav1.6, PN4, sodium voltage-gated channel alpha subunit 8, BFIS5, MYOCL2, DEE13
External IDs	OMIM: 600702; MGI: 103169; HomoloGene: 7927; GeneCards: SCN8A; OMA:SCN8A - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	51,812,864 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	100,943,819 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; postcentral gyrus; ; primary visual cortex; ; superior frontal gyrus; ; endothelial cell; ; entorhinal cortex; ; lateral nuclear group of thalamus; ; buccal mucosa cell; ; right hemisphere of cerebellum;
	Top expressed in
	pontine nuclei; ; subiculum; ; cerebellar vermis; ; prefrontal cortex; ; primary motor cortex; ; deep cerebellar nuclei; ; medial dorsal nucleus; ; medial vestibular nucleus; ; lobe of cerebellum; ; lateral geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; sodium channel activity; voltage-gated ion channel activity; ion channel activity; ATP binding; protein binding; voltage-gated sodium channel activity;
Cellular component	voltage-gated sodium channel complex; integral component of membrane; membrane; node of Ranvier; Z discdkac; axon initial segment; cytoplasmic vesicle; plasma membrane; axon;
Biological process	membrane depolarization during action potential; peripheral nervous system development; sodium ion transport; regulation of ion transmembrane transport; ion transport; nervous system development; ion transmembrane transport; transmembrane transport; myelination; neuronal action potential; sodium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6334
	20273
	ENSG00000196876
	ENSMUSG00000023033
	Q9UQD0
	Q9WTU3
	NM_001177984; NM_014191; NM_175894; NM_001330260; NM_001369788
	NM_001077499; NM_011323
	NP_001171455; NP_001317189; NP_055006; NP_001356717
	NP_001070967; NP_035453
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium channel protein type 8 subunit alpha also known as Na_v1.6 is a membrane protein encoded by the SCN8A gene.^[5]^[6] Na_v1.6 is one sodium channel isoform and is the primary voltage-gated sodium channel at each node of Ranvier. The channels are highly concentrated in sensory and motor axons in the peripheral nervous system and cluster at the nodes in the central nervous system.^[7]^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196876 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023033 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "UniProt". www.uniprot.org. Retrieved 25 July 2022.
^ "Entrez Gene: SCN8A sodium channel, voltage gated, type VIII, alpha subunit".
^ Caldwell JH, Schaller KL, Lasher RS, Peles E, Levinson SR (May 2000). "Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses". Proceedings of the National Academy of Sciences of the United States of America. 97 (10): 5616–20. Bibcode:2000PNAS...97.5616C. doi:10.1073/pnas.090034797. PMC 25877. PMID 10779552.
^ Boiko T, Rasband MN, Levinson SR, Caldwell JH, Mandel G, Trimmer JS, Matthews G (April 2001). "Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon". Neuron. 30 (1): 91–104. doi:10.1016/s0896-6273(01)00265-3. PMID 11343647. S2CID 7168889.
^ Tzoumaka E, Tischler AC, Sangameswaran L, Eglen RM, Hunter JC, Novakovic SD (April 2000). "Differential distribution of the tetrodotoxin-sensitive rPN4/NaCh6/Scn8a sodium channel in the nervous system". Journal of Neuroscience Research. 60 (1): 37–44. doi:10.1002/(SICI)1097-4547(20000401)60:1<37::AID-JNR4>3.0.CO;2-W. PMID 10723066. S2CID 46539625.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196876 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023033 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[UniProt-5] "UniProt". www.uniprot.org. Retrieved 25 July 2022.

[entrez-6] "Entrez Gene: SCN8A sodium channel, voltage gated, type VIII, alpha subunit".

[7] Caldwell JH, Schaller KL, Lasher RS, Peles E, Levinson SR (May 2000). "Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses". Proceedings of the National Academy of Sciences of the United States of America. 97 (10): 5616–20. Bibcode:2000PNAS...97.5616C. doi:10.1073/pnas.090034797. PMC 25877. PMID 10779552.

[ReferenceA-8] Boiko T, Rasband MN, Levinson SR, Caldwell JH, Mandel G, Trimmer JS, Matthews G (April 2001). "Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon". Neuron. 30 (1): 91–104. doi:10.1016/s0896-6273(01)00265-3. PMID 11343647. S2CID 7168889.

[9] Tzoumaka E, Tischler AC, Sangameswaran L, Eglen RM, Hunter JC, Novakovic SD (April 2000). "Differential distribution of the tetrodotoxin-sensitive rPN4/NaCh6/Scn8a sodium channel in the nervous system". Journal of Neuroscience Research. 60 (1): 37–44. doi:10.1002/(SICI)1097-4547(20000401)60:1<37::AID-JNR4>3.0.CO;2-W. PMID 10723066. S2CID 46539625.

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