SDHA

SDHA
Identifiers
Aliases	SDHA, CMD1GG, FP, PGL5, SDH1, SDH2, SDHF, succinate dehydrogenase complex flavoprotein subunit A, MC2DN1, NDAXOA
External IDs	OMIM: 600857; MGI: 1914195; HomoloGene: 3073; GeneCards: SDHA; OMA:SDHA - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.33 Start 218,303 bp[1] End 257,082 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C1 Start 74,470,373 bp[2] End 74,498,399 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart left ventricle mucosa of transverse colon right auricle skeletal muscle tissue muscle of thigh duodenum gastrocnemius muscle right lobe of liver right adrenal cortex Top expressed in right ventricle sternocleidomastoid muscle digastric muscle temporal muscle right kidney vastus lateralis muscle triceps brachii muscle aortic valve medial head of gastrocnemius muscle supraoptic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors succinate dehydrogenase activity protein binding succinate dehydrogenase (ubiquinone) activity flavin adenine dinucleotide binding electron transfer activity Cellular component mitochondrial inner membrane myelin sheath mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) membrane mitochondrion nucleolus plasma membrane succinate dehydrogenase complex Biological process succinate metabolic process tricarboxylic acid cycle nervous system development electron transport chain respiratory electron transport chain mitochondrial electron transport, succinate to ubiquinone anaerobic respiration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6389 66945 Ensembl ENSG00000073578 ENSMUSG00000021577 UniProt P31040 Q8K2B3 RefSeq (mRNA) NM_001294332 NM_004168 NM_001330758 NM_023281 RefSeq (protein) NP_001281261 NP_001317687 NP_004159 NP_075770 Location (UCSC) Chr 5: 0.22 – 0.26 Mb Chr 13: 74.47 – 74.5 Mb PubMed search [3] [4]
Wikidata
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Succinate dehydrogenase complex, subunit A, flavoprotein variant is a protein that in humans is encoded by the SDHA gene.^[5] This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. SDHA contains the FAD binding site where succinate is deprotonated and converted to fumarate. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[6]