SEC63

SEC63
Identifiers
Aliases	SEC63, DNAJC23, ERdj2, PRO2507, SEC63L, SEC63 homolog, protein translocation regulator, PCLD2
External IDs	OMIM: 608648; MGI: 2155302; HomoloGene: 5220; GeneCards: SEC63; OMA:SEC63 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	107,958,208 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	42,708,510 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; body of pancreas; ; parotid gland; ; stromal cell of endometrium; ; bone marrow cells; ; ganglionic eminence; ; ventricular zone; ; left ovary; ; olfactory zone of nasal mucosa; ; right ovary;
	Top expressed in
	seminal vesicula; ; parotid gland; ; lacrimal gland; ; neural layer of retina; ; saccule; ; ventricular zone; ; left lobe of liver; ; tail of embryo; ; otic placode; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding; signaling receptor activity;
Cellular component	endoplasmic reticulum membrane; cytosol; integral component of membrane; membrane; endoplasmic reticulum; Sec62/Sec63 complex;
Biological process	IRE1-mediated unfolded protein response; protein targeting to membrane; liver development; protein transport; SRP-dependent cotranslational protein targeting to membrane; multicellular organism aging; renal system development; nitrogen compound metabolic process; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation; transport;
	Sources:Amigo / QuickGO
Orthologs
	11231
	140740
	ENSG00000025796
	ENSMUSG00000019802
	Q9UGP8
	Q8VHE0
	NM_007214; NM_018529
	NM_153055; NM_001359283; NM_001359284; NM_001359285; NM_001359286
	NP_009145
	NP_694695; NP_001346212; NP_001346213; NP_001346214; NP_001346215
	Wikidata
View/Edit Human	View/Edit Mouse

Translocation protein SEC63 homolog is a protein that in humans is encoded by the SEC63 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000025796 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019802 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Woollatt E, Pine KA, Shine J, Sutherland GR, Iismaa TP (Jun 1999). "Human Sec63 endoplasmic reticulum membrane protein, map position 6q21". Chromosome Res. 7 (1): 77. doi:10.1023/A:1009283530544. PMID 10219736. S2CID 19417266.
^ Skowronek MH, Rotter M, Haas IG (Nov 1999). "Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog". Biol Chem. 380 (9): 1133–8. doi:10.1515/BC.1999.142. PMID 10543453. S2CID 46726981.
^ "Entrez Gene: SEC63 SEC63 homolog (S. cerevisiae)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000025796 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019802 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10219736-5] Woollatt E, Pine KA, Shine J, Sutherland GR, Iismaa TP (Jun 1999). "Human Sec63 endoplasmic reticulum membrane protein, map position 6q21". Chromosome Res. 7 (1): 77. doi:10.1023/A:1009283530544. PMID 10219736. S2CID 19417266.

[pmid10543453-6] Skowronek MH, Rotter M, Haas IG (Nov 1999). "Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog". Biol Chem. 380 (9): 1133–8. doi:10.1515/BC.1999.142. PMID 10543453. S2CID 46726981.

[entrez-7] "Entrez Gene: SEC63 SEC63 homolog (S. cerevisiae)".

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