SERPINB1

SERPINB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GA7
Identifiers
Aliases	SERPINB1, EI, ELANH2, HEL57, LEI, M/NEI, MNEI, PI-2, PI2, HEL-S-27, serpin family B member 1
External IDs	OMIM: 130135; MGI: 1913472; HomoloGene: 133768; GeneCards: SERPINB1; OMA:SERPINB1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	2,841,959 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	33,035,168 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; oral cavity; ; bone marrow; ; monocyte; ; palpebral conjunctiva; ; body of pancreas; ; jejunal mucosa; ; trabecular bone; ; bone marrow cells; ; duodenum;
	Top expressed in
	granulocyte; ; left colon; ; jejunum; ; duodenum; ; mucous cell of stomach; ; esophagus; ; tibiofemoral joint; ; epithelium of stomach; ; ileum; ; Paneth cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; serine-type endopeptidase inhibitor activity; protein binding;
Cellular component	cytoplasm; extracellular exosome; membrane; extracellular space; secretory granule lumen; extracellular matrix; extracellular region; collagen-containing extracellular matrix;
Biological process	negative regulation of peptidase activity; negative regulation of endopeptidase activity; neutrophil degranulation; type B pancreatic cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1992
	66222
	ENSG00000021355
	ENSMUSG00000044734
	P30740
	Q9D154
	NM_030666
	NM_025429
	NP_109591
	NP_079705
	Wikidata
View/Edit Human	View/Edit Mouse

Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins (ovalbumin related serpins) founded by ovalbumin.^[5]^[6]^[7]

MNEI (monocyte/neutrophil elastase inhibitor) is the mouse orthologue of human SerpinB1.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000021355 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044734 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Remold-O'Donnell E, Chin J, Alberts M (Jul 1992). "Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor". Proc Natl Acad Sci U S A. 89 (12): 5635–9. Bibcode:1992PNAS...89.5635R. doi:10.1073/pnas.89.12.5635. PMC 49347. PMID 1376927.
^ "Entrez Gene: SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1".
^ ^a ^b Benarafa C, Remold-O'Donnell E (August 2005). "The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates". Proc. Natl. Acad. Sci. U.S.A. 102 (32): 11367–72. Bibcode:2005PNAS..10211367B. doi:10.1073/pnas.0502934102. PMC 1183561. PMID 16055559.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000021355 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044734 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1376927-5] Remold-O'Donnell E, Chin J, Alberts M (Jul 1992). "Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor". Proc Natl Acad Sci U S A. 89 (12): 5635–9. Bibcode:1992PNAS...89.5635R. doi:10.1073/pnas.89.12.5635. PMC 49347. PMID 1376927.

[entrez-6] "Entrez Gene: SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1".

[Benarafa_2005-7] Benarafa C, Remold-O'Donnell E (August 2005). "The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates". Proc. Natl. Acad. Sci. U.S.A. 102 (32): 11367–72. Bibcode:2005PNAS..10211367B. doi:10.1073/pnas.0502934102. PMC 1183561. PMID 16055559.

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