SERPINB3

SERPINB3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZV6, 4ZK0, 4ZK3
Identifiers
Aliases	SERPINB3, HsT1196, SCC, SCCA-1, SCCA-PD, SCCA1, T4-A, SSCA1, serpin family B member 3
External IDs	OMIM: 600517; MGI: 2683295; HomoloGene: 130559; GeneCards: SERPINB3; OMA:SERPINB3 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	63,661,893 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	107,011,236 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; nasal epithelium; ; vulva; ; human penis; ; mucosa of paranasal sinus; ; epithelium of bronchus; ; bronchial epithelial cell; ; gums; ; gingival epithelium; ; mucosa of pharynx;
	Top expressed in
	thymus; ; esophagus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; protease binding; cysteine-type endopeptidase inhibitor activity; peptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Cellular component	nucleus; vesicle; cytoplasmic vesicle; extracellular exosome; cytoplasm; extracellular region; extracellular space; azurophil granule lumen;
Biological process	paracrine signaling; positive regulation of cell population proliferation; autocrine signaling; negative regulation of catalytic activity; negative regulation of JUN kinase activity; positive regulation of endopeptidase activity; positive regulation of epithelial to mesenchymal transition; negative regulation of proteolysis; negative regulation of endopeptidase activity; positive regulation of cell migration; viral entry into host cell; negative regulation of peptidase activity; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	6317
	394252
	ENSG00000057149
	ENSMUSG00000058017
	P29508
	Q6UKZ0
	NM_006919
	NM_201376
	NP_008850
	NP_958764
	Wikidata
View/Edit Human	View/Edit Mouse

Serpin B3 is a protein that in humans is encoded by the SERPINB3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000057149 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058017 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA (May 1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene". Proc Natl Acad Sci U S A. 92 (8): 3147–51. Bibcode:1995PNAS...92.3147S. doi:10.1073/pnas.92.8.3147. PMC 42122. PMID 7724531.
^ "Entrez Gene: SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000057149 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058017 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7724531-5] Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA (May 1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene". Proc Natl Acad Sci U S A. 92 (8): 3147–51. Bibcode:1995PNAS...92.3147S. doi:10.1073/pnas.92.8.3147. PMC 42122. PMID 7724531.

[entrez-6] "Entrez Gene: SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3".

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