SERPINB6

SERPINB6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M37
Identifiers
Aliases	SERPINB6, CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3, serpin family B member 6
External IDs	OMIM: 173321; MGI: 103123; HomoloGene: 20956; GeneCards: SERPINB6; OMA:SERPINB6 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	2,972,165 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	34,186,777 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right uterine tube; ; body of pancreas; ; apex of heart; ; left ovary; ; right auricle; ; right ovary; ; canal of the cervix; ; right adrenal gland;
	Top expressed in
	stroma of bone marrow; ; ankle joint; ; endothelial cell of lymphatic vessel; ; Ileal epithelium; ; submandibular gland; ; esophagus; ; ovary; ; skin of external ear; ; umbilical cord; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; protease binding; serine-type endopeptidase inhibitor activity;
Cellular component	cytoplasm; cytosol; extracellular exosome; nucleus; extracellular space; plasma membrane; secretory granule membrane; tertiary granule membrane; ficolin-1-rich granule membrane; extracellular region; collagen-containing extracellular matrix; serine protease inhibitor complex;
Biological process	negative regulation of peptidase activity; hearing; cellular response to osmotic stress; negative regulation of endopeptidase activity; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	5269
	20719
	ENSG00000124570
	ENSMUSG00000060147
	P35237
	Q60854
NM_001195291; NM_001271822; NM_001271823; NM_001271824; NM_001271825;
	NM_001297699; NM_001297700; NM_004568; NM_001374515; NM_001374516; NM_001374517
	NM_001164117; NM_001164118; NM_001243192; NM_009254
NP_001182220; NP_001258751; NP_001258752; NP_001258753; NP_001258754;
	NP_001284628; NP_001284629; NP_004559; NP_001361444; NP_001361445; NP_001361446
	NP_001157589; NP_001157590; NP_001230121; NP_033280
	Wikidata
View/Edit Human	View/Edit Mouse

Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124570 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060147 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Coughlin P, Sun J, Cerruti L, Salem HH, Bird P (Nov 1993). "Cloning and molecular characterization of a human intracellular serine proteinase inhibitor". Proc Natl Acad Sci U S A. 90 (20): 9417–21. Bibcode:1993PNAS...90.9417C. doi:10.1073/pnas.90.20.9417. PMC 47579. PMID 8415716.
^ Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet. 82 (3–4): 273–7. doi:10.1159/000015118. PMID 9858835. S2CID 23659776.
^ "Entrez Gene: SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124570 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060147 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8415716-5] Coughlin P, Sun J, Cerruti L, Salem HH, Bird P (Nov 1993). "Cloning and molecular characterization of a human intracellular serine proteinase inhibitor". Proc Natl Acad Sci U S A. 90 (20): 9417–21. Bibcode:1993PNAS...90.9417C. doi:10.1073/pnas.90.20.9417. PMC 47579. PMID 8415716.

[pmid9858835-6] Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet. 82 (3–4): 273–7. doi:10.1159/000015118. PMID 9858835. S2CID 23659776.

[entrez-7] "Entrez Gene: SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6".

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