SERPINB8

SERPINB8
Identifiers
Aliases	SERPINB8, CAP2, PI8, serpin family B member 8, PSS5, PI-8, HMSD, HSMD-v, C18orf53
External IDs	OMIM: 601697; MGI: 894657; HomoloGene: 74445; GeneCards: SERPINB8; OMA:SERPINB8 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	64,019,779 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	107,538,214 bp
RNA expression pattern
	Top expressed in
	monocyte; ; skin of leg; ; skin of abdomen; ; granulocyte; ; gallbladder; ; islet of Langerhans; ; gingival epithelium; ; Descending thoracic aorta; ; tibial arteries; ; testicle;
	Top expressed in
	lumbar spinal ganglion; ; esophagus; ; skin of external ear; ; lip; ; skin of back; ; conjunctival fornix; ; skin of abdomen; ; stroma of bone marrow; ; epidermis; ; cervix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity;
Cellular component	cytoplasm; cytosol; extracellular exosome; extracellular space; collagen-containing extracellular matrix;
Biological process	negative regulation of peptidase activity; negative regulation of endopeptidase activity; epithelial cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	5271
	20725
	ENSG00000166401
	ENSMUSG00000026315
	P50452
	O08800
NM_001031848; NM_001276490; NM_002640; NM_198833; NM_001348367;
	NM_001348368; NM_001348369; NM_001348370; NM_001366198
	NM_001159748; NM_011459
NP_001027018; NP_001263419; NP_002631; NP_942130; NP_001335296;
	NP_001335297; NP_001335298; NP_001335299; NP_001353127
	NP_001153220; NP_035589
	Wikidata
View/Edit Human	View/Edit Mouse

Serpin B8 is a protein that in humans is encoded by the SERPINB8 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166401 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026315 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sprecher CA, Morgenstern KA, Mathewes S, Dahlen JR, Schrader SK, Foster DC, Kisiel W (Jan 1996). "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors". J Biol Chem. 270 (50): 29854–61. doi:10.1074/jbc.270.50.29854. PMID 8530382.
^ Bartuski AJ, Kamachi Y, Schick C, Overhauser J, Silverman GA (Nov 1997). "Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3". Genomics. 43 (3): 321–8. doi:10.1006/geno.1997.4827. PMID 9268635.
^ "Entrez Gene: SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166401 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026315 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530382-5] Sprecher CA, Morgenstern KA, Mathewes S, Dahlen JR, Schrader SK, Foster DC, Kisiel W (Jan 1996). "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors". J Biol Chem. 270 (50): 29854–61. doi:10.1074/jbc.270.50.29854. PMID 8530382.

[pmid9268635-6] Bartuski AJ, Kamachi Y, Schick C, Overhauser J, Silverman GA (Nov 1997). "Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3". Genomics. 43 (3): 321–8. doi:10.1006/geno.1997.4827. PMID 9268635.

[entrez-7] "Entrez Gene: SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8".

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