SERPINE2

SERPINE2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DY0, 4DY7
Identifiers
Aliases	SERPINE2, GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI, serpin family E member 2
External IDs	OMIM: 177010; MGI: 101780; HomoloGene: 21247; GeneCards: SERPINE2; OMA:SERPINE2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	224,039,318 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	79,838,897 bp
RNA expression pattern
	Top expressed in
	decidua; ; cartilage tissue; ; stromal cell of endometrium; ; ventral tegmental area; ; tibia; ; paraflocculus of cerebellum; ; spinal ganglia; ; external globus pallidus; ; trigeminal ganglion; ; superior vestibular nucleus;
	Top expressed in
	seminal vesicula; ; tunica media of zone of aorta; ; calvaria; ; stroma of bone marrow; ; cumulus cell; ; olfactory epithelium; ; tibiofemoral joint; ; body of femur; ; ventral tegmental area; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; glycosaminoglycan binding; peptidase inhibitor activity; heparin binding; serine-type endopeptidase inhibitor activity; signaling receptor binding;
Cellular component	extracellular vesicle; extrinsic component of external side of plasma membrane; platelet alpha granule; extracellular matrix; cytosol; neuromuscular junction; extracellular region; extracellular space; collagen-containing extracellular matrix;
Biological process	negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of cell growth; seminal vesicle epithelium development; secretory granule organization; innervation; mating plug formation; nervous system development; detection of mechanical stimulus involved in sensory perception; multicellular organism development; regulation of cell migration; long-term potentiation; regulation of timing of cell differentiation; cell differentiation; negative regulation of proteolysis; negative regulation of protein catabolic process; negative regulation of plasminogen activation; cerebellar granular layer morphogenesis; negative regulation of cell population proliferation; secretion by cell; negative regulation of sodium ion transport; negative regulation of smoothened signaling pathway; negative regulation of protein processing; positive regulation of astrocyte differentiation; negative regulation of platelet activation; response to wounding; regulation of synaptic transmission, glutamatergic; negative regulation of peptidase activity; negative regulation of blood coagulation; blood coagulation; negative regulation of platelet aggregation; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	5270
	20720
	ENSG00000135919
	ENSMUSG00000026249
	P07093
	Q07235
	NM_001136528; NM_001136530; NM_006216
	NM_009255
	NP_001130000; NP_001130002; NP_006207
	NP_033281
	Wikidata
View/Edit Human	View/Edit Mouse

Glia-derived nexin is a protein that in humans is encoded by the SERPINE2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135919 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026249 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Carter RE, Cerosaletti KM, Burkin DJ, Fournier RE, Jones C, Greenberg BD, Citron BA, Festoff BW (Oct 1995). "The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes". Genomics. 27 (1): 196–9. doi:10.1006/geno.1995.1025. PMID 7665170.
^ "Entrez Gene: SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135919 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026249 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7665170-5] Carter RE, Cerosaletti KM, Burkin DJ, Fournier RE, Jones C, Greenberg BD, Citron BA, Festoff BW (Oct 1995). "The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes". Genomics. 27 (1): 196–9. doi:10.1006/geno.1995.1025. PMID 7665170.

[entrez-6] "Entrez Gene: SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2".

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