SGCB

SGCB
Identifiers
Aliases	SGCB, A3b, LGMD2E, SGC, sarcoglycan beta, LGMDR4
External IDs	OMIM: 600900; MGI: 1346523; HomoloGene: 195; GeneCards: SGCB; OMA:SGCB - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	52,038,299 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	73,805,133 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; right ventricle; ; ganglionic eminence; ; internal globus pallidus; ; trigeminal ganglion; ; ventricular zone; ; sperm; ; tibia;
	Top expressed in
	triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; right ventricle; ; digastric muscle; ; ankle; ; muscle of thigh; ; myocardium of ventricle; ; intercostal muscle; ; quadriceps femoris muscle;
	More reference expression data
	; ;
	More reference expression data
Orthologs
	6443
	24051
	ENSG00000163069
	ENSMUSG00000029156
	Q16585; Q5U0N0
	P82349
	NM_000232
	NM_011890
	NP_000223; NP_000223.1
	NP_036020
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-sarcoglycan is a protein that in humans is encoded by the SGCB gene.^[5]^[6]

The dystrophin-glycoprotein complex (DGC) is a multisubunit protein complex that spans the sarcolemma and provides structural linkage between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. There are 3 main subcomplexes of the DGC: the cytoplasmic proteins dystrophin (DMD; MIM 300377) and syntrophin (SNTA1; MIM 601017), the alpha- and beta-dystroglycans (see MIM 128239), and the sarcoglycans (see, e.g., SGCA; MIM 600119) (Crosbie et al., 2000).[supplied by OMIM].^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163069 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029156 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bonnemann CG, Passos-Bueno MR, McNally EM, Vainzof M, de Sa Moreira E, Marie SK, Pavanello RC, Noguchi S, Ozawa E, Zatz M, Kunkel LM (Mar 1997). "Genomic screening for beta-sarcoglycan gene mutations: missense mutations may cause severe limb-girdle muscular dystrophy type 2E (LGMD 2E)". Hum Mol Genet. 5 (12): 1953–61. doi:10.1093/hmg/5.12.1953. PMID 8968749.
^ ^a ^b "Entrez Gene: SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163069 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029156 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8968749-5] Bonnemann CG, Passos-Bueno MR, McNally EM, Vainzof M, de Sa Moreira E, Marie SK, Pavanello RC, Noguchi S, Ozawa E, Zatz M, Kunkel LM (Mar 1997). "Genomic screening for beta-sarcoglycan gene mutations: missense mutations may cause severe limb-girdle muscular dystrophy type 2E (LGMD 2E)". Hum Mol Genet. 5 (12): 1953–61. doi:10.1093/hmg/5.12.1953. PMID 8968749.

[entrez-6] "Entrez Gene: SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)".

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