SH2B1

SH2B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HDV, 2HDX
Identifiers
Aliases	SH2B1, PSM, SH2B, SH2B adaptor protein 1
External IDs	OMIM: 608937; MGI: 1201407; HomoloGene: 32122; GeneCards: SH2B1; OMA:SH2B1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	28,874,212 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,074,596 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; mucosa of transverse colon; ; right lobe of thyroid gland; ; right uterine tube; ; apex of heart; ; left lobe of thyroid gland; ; anterior pituitary; ; right ovary; ; left ovary; ; right frontal lobe;
	Top expressed in
	neural layer of retina; ; granulocyte; ; muscle of thigh; ; molar; ; lip; ; superior frontal gyrus; ; primary visual cortex; ; thymus; ; ankle; ; quadriceps femoris muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signaling adaptor activity; protein binding; transmembrane receptor protein tyrosine kinase adaptor activity;
Cellular component	cytosol; nucleus; membrane; cytoplasm; plasma membrane;
Biological process	positive regulation of signal transduction; positive regulation of mitotic nuclear division; blood coagulation; lamellipodium assembly; signal transduction; regulation of DNA biosynthetic process; transmembrane receptor protein tyrosine kinase signaling pathway; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	25970
	20399
	ENSG00000178188
	ENSMUSG00000030733
	Q9NRF2
	Q91ZM2
NM_001145795; NM_001145796; NM_001145797; NM_001145812; NM_001308293;
	NM_001308294; NM_015503; NM_001387404; NM_001387430
NM_001081459; NM_001289538; NM_001289539; NM_001289540; NM_001289541;
	NM_001289542; NM_011363
NP_001139267; NP_001139268; NP_001139269; NP_001139284; NP_001295222;
	NP_001295223; NP_056318
NP_001074928; NP_001276467; NP_001276468; NP_001276469; NP_001276470;
	NP_001276471; NP_035493
	Wikidata
View/Edit Human	View/Edit Mouse

SH2B adapter protein 1 is a protein that in humans is encoded by the SH2B1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178188 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030733 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kong M, Wang CS, Donoghue DJ (Apr 2002). "Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation". J Biol Chem. 277 (18): 15962–70. doi:10.1074/jbc.M102777200. PMID 11827956.
^ Nelms K, O'Neill TJ, Li S, Hubbard SR, Gustafson TA, Paul WE (Jan 2000). "Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain". Mamm Genome. 10 (12): 1160–7. doi:10.1007/s003359901183. PMID 10594240. S2CID 21060861.
^ "Entrez Gene: SH2B1 SH2B adaptor protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178188 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030733 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11827956-5] Kong M, Wang CS, Donoghue DJ (Apr 2002). "Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation". J Biol Chem. 277 (18): 15962–70. doi:10.1074/jbc.M102777200. PMID 11827956.

[pmid10594240-6] Nelms K, O'Neill TJ, Li S, Hubbard SR, Gustafson TA, Paul WE (Jan 2000). "Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain". Mamm Genome. 10 (12): 1160–7. doi:10.1007/s003359901183. PMID 10594240. S2CID 21060861.

[entrez-7] "Entrez Gene: SH2B1 SH2B adaptor protein 1".

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