SHC1

SHC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSHC1, SHC, SHCA, SHC adaptor protein 1
External IDsOMIM: 600560; MGI: 98296; HomoloGene: 7934; GeneCards: SHC1; OMA:SHC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001130040
NM_001130041
NM_001202859
NM_003029
NM_183001

NM_001113331
NM_011368

RefSeq (protein)

NP_001123512
NP_001123513
NP_001189788
NP_003020
NP_892113

NP_001106802
NP_035498

Location (UCSC)Chr 1: 154.96 – 154.97 MbChr 3: 89.33 – 89.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene.[5] SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells.

SCOP classifies the 3D structure as belonging to the SH2 domain family.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160691Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042626Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG (Jul 1992). "A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction". Cell. 70 (1): 93–104. doi:10.1016/0092-8674(92)90536-L. PMID 1623525. S2CID 20390181.