SIGLEC8

SIGLEC8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N7B, 2N7A
Identifiers
Aliases	SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L, sialic acid binding Ig like lectin 8
External IDs	OMIM: 605639; MGI: 2681107; HomoloGene: 50482; GeneCards: SIGLEC8; OMA:SIGLEC8 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,458,456 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,008,955 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; spleen; ; lymph node; ; right adrenal cortex; ; left adrenal gland; ; substantia nigra; ; left adrenal cortex; ; internal globus pallidus; ; prefrontal cortex; ; gallbladder;
	Top expressed in
	granulocyte; ; right lung lobe; ; primary oocyte; ; embryo; ; secondary oocyte; ; morula; ; blood; ; zygote; ; bone marrow; ; intestinal villus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; transmembrane signaling receptor activity; carbohydrate binding;
Cellular component	integral component of membrane; membrane;
Biological process	cell adhesion; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	27181
	233186
	ENSG00000105366
	ENSMUSG00000039013
	Q9NYZ4
	Q920G3
	NM_014442; NM_001363548
	NM_001271019; NM_145581
	NP_055257; NP_001350477
	NP_001257948; NP_663556
	Wikidata
View/Edit Human	View/Edit Mouse

Sialic acid-binding Ig-like lectin 8 is a protein that in humans is encoded by the SIGLEC8 gene.^[5]^[6] This gene is located on chromosome 19q13.4, about 330 kb downstream of the SIGLEC9 gene.^[5]^[7] Within the siglec family of transmembrane proteins, Siglec-8 belongs to the CD33-related siglec subfamily, a subfamily that has undergone rapid evolution.^[8]^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105366 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039013 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Floyd H, Ni J, Cornish AL, Zeng Z, Liu D, Carter KC, Steel J, Crocker PR (January 2000). "Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily". The Journal of Biological Chemistry. 275 (2): 861–6. doi:10.1074/jbc.275.2.861. PMID 10625619.
^ "Entrez Gene: SIGLEC8 sialic acid binding Ig-like lectin 8".
^ Foussias G, Yousef GM, Diamandis EP (November 2000). "Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene". Biochemical and Biophysical Research Communications. 278 (3): 775–81. doi:10.1006/bbrc.2000.3866. PMID 11095983.
^ Kikly KK, Bochner BS, Freeman SD, Tan KB, Gallagher KT, D'alessio KJ, Holmes SD, Abrahamson JA, Erickson-Miller CL, Murdock PR, Tachimoto H, Schleimer RP, White JR (June 2000). "Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils". The Journal of Allergy and Clinical Immunology. 105 (6 Pt 1): 1093–100. doi:10.1067/mai.2000.107127. PMID 10856141.
^ Angata T, Margulies EH, Green ED, Varki A (September 2004). "Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms". Proceedings of the National Academy of Sciences of the United States of America. 101 (36): 13251–6. Bibcode:2004PNAS..10113251A. doi:10.1073/pnas.0404833101. PMC 516556. PMID 15331780.
^ Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T (March 2014). "Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates". FASEB Journal. 28 (3): 1280–93. doi:10.1096/fj.13-241497. PMC 3929681. PMID 24308974.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105366 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039013 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10625619-5] Floyd H, Ni J, Cornish AL, Zeng Z, Liu D, Carter KC, Steel J, Crocker PR (January 2000). "Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily". The Journal of Biological Chemistry. 275 (2): 861–6. doi:10.1074/jbc.275.2.861. PMID 10625619.

[entrez-6] "Entrez Gene: SIGLEC8 sialic acid binding Ig-like lectin 8".

[pmid11095983-7] Foussias G, Yousef GM, Diamandis EP (November 2000). "Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene". Biochemical and Biophysical Research Communications. 278 (3): 775–81. doi:10.1006/bbrc.2000.3866. PMID 11095983.

[pmid10856141-8] Kikly KK, Bochner BS, Freeman SD, Tan KB, Gallagher KT, D'alessio KJ, Holmes SD, Abrahamson JA, Erickson-Miller CL, Murdock PR, Tachimoto H, Schleimer RP, White JR (June 2000). "Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils". The Journal of Allergy and Clinical Immunology. 105 (6 Pt 1): 1093–100. doi:10.1067/mai.2000.107127. PMID 10856141.

[pmid15331780-9] Angata T, Margulies EH, Green ED, Varki A (September 2004). "Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms". Proceedings of the National Academy of Sciences of the United States of America. 101 (36): 13251–6. Bibcode:2004PNAS..10113251A. doi:10.1073/pnas.0404833101. PMC 516556. PMID 15331780.

[pmid24308974-10] Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T (March 2014). "Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates". FASEB Journal. 28 (3): 1280–93. doi:10.1096/fj.13-241497. PMC 3929681. PMID 24308974.

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