SIN3A

SIN3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PO4
Identifiers
Aliases	SIN3A, Paired amphipathic helix protein Sin3a, SIN3 transcription regulator family member A, WITKOS
External IDs	OMIM: 607776; MGI: 107157; HomoloGene: 32124; GeneCards: SIN3A; OMA:SIN3A - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	75,455,842 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	57,035,650 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; pancreatic ductal cell; ; bone marrow cells; ; testicle; ; ganglionic eminence; ; Achilles tendon; ; mucosa of ileum; ; tibial arteries; ; skin of limb;
	Top expressed in
	zygote; ; secondary oocyte; ; tail of embryo; ; primary oocyte; ; genital tubercle; ; ectoderm; ; otic placode; ; otic vesicle; ; saccule; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; transcription corepressor activity; histone deacetylase activity; DNA-binding transcription factor activity; protein deacetylase activity; transcription factor binding; chromatin binding; transcription cis-regulatory region binding; protein binding; RNA binding; protein-containing complex binding;
Cellular component	transcription regulator complex; transcription repressor complex; nucleoplasm; nucleolus; chromatin; nucleus; kinetochore; Sin3 complex; protein-containing complex;
Biological process	negative regulation of protein localization to nucleus; regulation of transcription, DNA-templated; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; rhythmic process; cellular response to dopamine; response to methylglyoxal; negative regulation of circadian rhythm; regulation of hormone levels; human ageing; negative regulation of apoptotic process; in utero embryonic development; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; protein deacetylation; DNA replication; negative regulation of transcription regulatory region DNA binding; response to organonitrogen compound; hematopoietic progenitor cell differentiation; activation of innate immune response; positive regulation of G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-templated; histone deacetylation; negative regulation of histone H3-K27 acetylation; cellular response to glucose stimulus; positive regulation of transcription by RNA polymerase II; positive regulation of defense response to virus by host; regulation of lipid metabolic process; regulation of megakaryocyte differentiation; negative regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	25942
	20466
	ENSG00000169375
	ENSMUSG00000042557
	Q96ST3
	Q60520
	NM_001145357; NM_001145358; NM_015477
	NM_001110350; NM_001110351; NM_011378; NM_001357754
	NP_001138829; NP_001138830; NP_056292
	NP_001103820; NP_001103821; NP_035508; NP_001344683
	Wikidata
View/Edit Human	View/Edit Mouse

Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169375 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042557 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yu F, Thiesen J, Strätling WH (May 2000). "Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2". Nucleic Acids Research. 28 (10): 2201–6. doi:10.1093/nar/28.10.2201. PMC 105362. PMID 10773092.
^ Halleck MS, Pownall S, Harder KW, Duncan AM, Jirik FR, Schlegel RA (March 1995). "A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3". Genomics. 26 (2): 403–6. doi:10.1016/0888-7543(95)80229-F. PMID 7601471.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169375 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042557 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10773092-5] Yu F, Thiesen J, Strätling WH (May 2000). "Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2". Nucleic Acids Research. 28 (10): 2201–6. doi:10.1093/nar/28.10.2201. PMC 105362. PMID 10773092.

[pmid7601471-6] Halleck MS, Pownall S, Harder KW, Duncan AM, Jirik FR, Schlegel RA (March 1995). "A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3". Genomics. 26 (2): 403–6. doi:10.1016/0888-7543(95)80229-F. PMID 7601471.

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