SK3

KCNN3
Identifiers
Aliases	KCNN3, KCa2.3, SK3, SKCA3, hSK3, potassium calcium-activated channel subfamily N member 3, ZLS3
External IDs	OMIM: 602983; MGI: 2153183; HomoloGene: 20516; GeneCards: KCNN3; OMA:KCNN3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	154,870,281 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,582,439 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; pars reticulata; ; internal globus pallidus; ; pars compacta; ; dorsal motor nucleus of vagus nerve; ; ventral tegmental area; ; superior vestibular nucleus; ; entorhinal cortex; ; tendon of biceps brachii; ; lateral nuclear group of thalamus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; ascending aorta; ; primary visual cortex; ; aortic valve; ; ventricular zone; ; ganglionic eminence; ; embryo; ; supraoptic nucleus; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	small conductance calcium-activated potassium channel activity; calcium-activated potassium channel activity; calmodulin binding;
Cellular component	integral component of membrane; soma; plasma membrane; membrane; neuron projection;
Biological process	potassium ion transport; ion transport; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	3782
	140493
	ENSG00000143603
	ENSMUSG00000000794
	Q9UGI6
	P58391
	NM_170782; NM_001204087; NM_002249; NM_001365837; NM_001365838
	NM_080466
	NP_001191016; NP_002240; NP_740752; NP_001352766; NP_001352767
	NP_536714
	Wikidata
View/Edit Human	View/Edit Mouse

SK3 (small conductance calcium-activated potassium channel 3) also known as K_Ca2.3 is a protein that in humans is encoded by the KCNN3 gene.^[5]^[6]

SK3 is a small-conductance calcium-activated potassium channel partly responsible for the calcium-dependent after hyperpolarisation current (I_AHP). It belongs to a family of channels known as small-conductance potassium channels, which consists of three members – SK1, SK2 and SK3 (encoded by the KCNN1, 2 and 3 genes respectively), which share a 60-70% sequence identity.^[7] These channels have acquired a number of alternative names, however a NC-IUPHAR has recently achieved consensus on the best names, K_Ca2.1 (SK1), K_Ca2.2 (SK2) and K_Ca2.3 (SK3).^[6] Small conductance channels are responsible for the medium and possibly the slow components of the I_AHP.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143603 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000794 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chandy KG, Fantino E, Wittekindt O, Kalman K, Tong LL, Ho TH, Gutman GA, Crocq MA, Ganguli R, Nimgaonkar V, Morris-Rosendahl DJ, Gargus JJ (January 1998). "Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder?". Mol. Psychiatry. 3 (1): 32–7. doi:10.1038/sj.mp.4000353. PMID 9491810.
^ ^a ^b Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (December 2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. S2CID 8290401.
^ Chen MX, Gorman SA, Benson B, Singh K, Hieble JP, Michel MC, Tate SN, Trezise DJ (June 2004). "Small and intermediate conductance Ca(2+)-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum". Naunyn-Schmiedeberg's Arch. Pharmacol. 369 (6): 602–15. doi:10.1007/s00210-004-0934-5. PMID 15127180. S2CID 6309146.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143603 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000794 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9491810-5] Chandy KG, Fantino E, Wittekindt O, Kalman K, Tong LL, Ho TH, Gutman GA, Crocq MA, Ganguli R, Nimgaonkar V, Morris-Rosendahl DJ, Gargus JJ (January 1998). "Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder?". Mol. Psychiatry. 3 (1): 32–7. doi:10.1038/sj.mp.4000353. PMID 9491810.

[pmid16382103-6] Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (December 2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. S2CID 8290401.

[pmid15127180-7] Chen MX, Gorman SA, Benson B, Singh K, Hieble JP, Michel MC, Tate SN, Trezise DJ (June 2004). "Small and intermediate conductance Ca(2+)-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum". Naunyn-Schmiedeberg's Arch. Pharmacol. 369 (6): 602–15. doi:10.1007/s00210-004-0934-5. PMID 15127180. S2CID 6309146.

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