SKIDA1

SKIDA1
Identifiers
Aliases	SKIDA1, C10orf140, DLN-1, SKI/DACH domain containing 1
External IDs	MGI: 1919918; HomoloGene: 66327; GeneCards: SKIDA1; OMA:SKIDA1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	21,526,368 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	18,053,862 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; ganglionic eminence; ; testicle; ; gonad; ; Brodmann area 23; ; buccal mucosa cell; ; ventricular zone; ; middle temporal gyrus; ; primary visual cortex; ; right lobe of thyroid gland;
	Top expressed in
	neural layer of retina; ; ventricular zone; ; genital tubercle; ; Rostral migratory stream; ; ganglionic eminence; ; right kidney; ; neural tube; ; embryo; ; yolk sac; ; embryo;
	More reference expression data
	n/a
Orthologs
	387640
	72668
	ENSG00000180592
	ENSMUSG00000054074
	Q1XH10
	Q80YR3
	NM_207371
	NM_028317
	NP_997254
	NP_082593
	Wikidata
View/Edit Human	View/Edit Mouse

Ski/Dach domain-containing protein 1 is a protein that in humans is encoded by the SKIDA1 gene.^[5] It is also known as C10orf140 and DLN-1. It has orthologs in vertebrates. It has two domains: the Ski/Sno/Dac domain and a domain of unknown function, DUF4854. It is associated with multiple types of cancer, like leukemia, ovarian cancer, and colon cancer.^[6]^[7] It's predicted to be a nuclear protein.^[8] It may interact with PRC2.^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180592 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054074 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "SKI/DACH domain-containing protein 1 [Homo sapiens]". NCBI. Retrieved 11 February 2019.
^ Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K, et al. (April 2013). "GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer". Nature Genetics. 45 (4): 362–70, 370e1-2. doi:10.1038/ng.2564. PMC 3693183. PMID 23535730.
^ Cortes-Ciriano I, Lee S, Park WY, Kim TM, Park PJ (June 2017). "A molecular portrait of microsatellite instability across multiple cancers". Nature Communications. 8: 15180. Bibcode:2017NatCo...815180C. doi:10.1038/ncomms15180. PMC 5467167. PMID 28585546.
^ Cite error: The named reference :4 was invoked but never defined (see the help page).
^ Liefke R, Shi Y (2015-04-28). "The PRC2-associated factor C17orf96 is a novel CpG island regulator in mouse ES cells". Cell Discovery. 1: 15008. doi:10.1038/celldisc.2015.8. PMC 4860827. PMID 27462409.
^ Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, et al. (October 2016). "A High-Density Map for Navigating the Human Polycomb Complexome". Cell Reports. 17 (2): 583–595. doi:10.1016/j.celrep.2016.08.096. hdl:20.500.11850/122094. PMID 27705803.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000180592 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054074 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] "SKI/DACH domain-containing protein 1 [Homo sapiens]". NCBI. Retrieved 11 February 2019.

[6] Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K, et al. (April 2013). "GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer". Nature Genetics. 45 (4): 362–70, 370e1-2. doi:10.1038/ng.2564. PMC 3693183. PMID 23535730.

[7] Cortes-Ciriano I, Lee S, Park WY, Kim TM, Park PJ (June 2017). "A molecular portrait of microsatellite instability across multiple cancers". Nature Communications. 8: 15180. Bibcode:2017NatCo...815180C. doi:10.1038/ncomms15180. PMC 5467167. PMID 28585546.

[:4-8] Cite error: The named reference :4 was invoked but never defined (see the help page).

[:1-9] Liefke R, Shi Y (2015-04-28). "The PRC2-associated factor C17orf96 is a novel CpG island regulator in mouse ES cells". Cell Discovery. 1: 15008. doi:10.1038/celldisc.2015.8. PMC 4860827. PMID 27462409.

[10] Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, et al. (October 2016). "A High-Density Map for Navigating the Human Polycomb Complexome". Cell Reports. 17 (2): 583–595. doi:10.1016/j.celrep.2016.08.096. hdl:20.500.11850/122094. PMID 27705803.

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