SKIP

INPP5K
Identifiers
Aliases	INPP5K, PPS, SKIP, inositol polyphosphate-5-phosphatase K, MDCCAID
External IDs	OMIM: 607875; MGI: 1194899; HomoloGene: 75059; GeneCards: INPP5K; OMA:INPP5K - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	1,516,742 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	75,539,697 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; right lung; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; apex of heart; ; granulocyte; ; skin of leg; ; upper lobe of left lung; ; gastric mucosa; ; skin of abdomen;
	Top expressed in
	retinal pigment epithelium; ; spermatocyte; ; spermatid; ; granulocyte; ; parotid gland; ; thymus; ; olfactory epithelium; ; right lung; ; right lung lobe; ; neural layer of retina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; inositol-1,4,5-trisphosphate 5-phosphatase activity; inositol bisphosphate phosphatase activity; inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol phosphate 5-phosphatase activity; phosphatidylinositol trisphosphate phosphatase activity; protein binding; lipid phosphatase activity; inositol trisphosphate phosphatase activity; hydrolase activity; vasopressin receptor activity; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;
Cellular component	cytoplasm; cytosol; membrane; ruffle; plasma membrane; ruffle membrane; trans-Golgi network; endoplasmic reticulum; perinuclear region of cytoplasm; neuron projection; nucleus;
Biological process	negative regulation of protein phosphorylation; G protein-coupled receptor signaling pathway; negative regulation of protein kinase B signaling; positive regulation of urine volume; negative regulation of dephosphorylation; negative regulation of protein kinase activity; glucose homeostasis; cellular response to tumor necrosis factor; negative regulation of peptidyl-threonine phosphorylation; in utero embryonic development; negative regulation of glycogen biosynthetic process; positive regulation of renal water transport; cellular response to epidermal growth factor stimulus; positive regulation of transcription, DNA-templated; response to insulin; negative regulation of insulin receptor signaling pathway; negative regulation of protein targeting to membrane; cellular response to hormone stimulus; negative regulation of glucose transmembrane transport; negative regulation of glycogen (starch) synthase activity; phosphatidylinositol dephosphorylation; negative regulation of MAP kinase activity; negative regulation of calcium ion transport; negative regulation of peptidyl-serine phosphorylation; cellular response to insulin stimulus; phosphatidylinositol biosynthetic process; regulation of glycogen biosynthetic process; negative regulation of stress fiber assembly; negative regulation of transcription, DNA-templated; ruffle assembly; inositol phosphate dephosphorylation; actin cytoskeleton organization; cellular response to cAMP; dephosphorylation; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; protein localization to plasma membrane; negative regulation by host of viral transcription; neuromuscular junction development, skeletal muscle fiber;
	Sources:Amigo / QuickGO
Orthologs
	51763
	19062
	ENSG00000132376
	ENSMUSG00000006127
	Q9BT40
	Q8C5L6
	NM_001135642; NM_016532; NM_130766
	NM_008916
	NP_001129114; NP_057616; NP_570122
	NP_032942
	Wikidata
View/Edit Human	View/Edit Mouse

SKIP is an acronym for Skeletal muscle and kidney enriched inositol phosphatase, which is a human gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132376 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006127 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SKIP skeletal muscle and kidney enriched inositol phosphatase".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132376 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006127 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SKIP skeletal muscle and kidney enriched inositol phosphatase".

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