SLC22A12

SLC22A12
Identifiers
Aliases	SLC22A12, solute carrier family 22 (organic anion/urate transporter), member 12, OAT4L, RST, URAT1, solute carrier family 22 member 12
External IDs	OMIM: 607096; MGI: 1195269; HomoloGene: 56442; GeneCards: SLC22A12; OMA:SLC22A12 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,602,353 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,593,062 bp
RNA expression pattern
	Top expressed in
	renal cortex; ; renal medulla; ; mammary gland; ; breast; ; human kidney; ; lactiferous gland; ; adipose tissue; ; liver; ; subcutaneous adipose tissue; ; serous sac;
	Top expressed in
	renal cortex; ; human kidney; ; right kidney; ; proximal tubule; ; outer renal medulla; ; proximal convoluted tubule; ; proximal straight tubule; ; distal tubule; ; primary visual cortex; ; hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	sodium-independent organic anion transmembrane transporter activity; PDZ domain binding; inorganic anion exchanger activity; urate transmembrane transporter activity; transmembrane transporter activity;
Cellular component	integral component of plasma membrane; extracellular exosome; apical plasma membrane; membrane; plasma membrane; integral component of membrane; brush border membrane;
Biological process	sodium-independent organic anion transport; urate transport; cellular homeostasis; ion transport; urate metabolic process; transmembrane transport; organic acid transmembrane transport; inorganic anion transport; transport; organic anion transport;
	Sources:Amigo / QuickGO
Orthologs
	116085
	20521
	ENSG00000197891
	ENSMUSG00000061742
	Q96S37
	Q8CFZ5
	NM_001276326; NM_001276327; NM_144585; NM_153378
	NM_009203
	NP_001263255; NP_001263256; NP_653186; NP_700357
	NP_033229
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 22 (organic anion/cation transporter), member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197891 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061742 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SLC22A12 solute carrier family 22 (organic anion/cation transporter), member 12".
^ Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H (May 2002). "Molecular identification of a renal urate anion exchanger that regulates blood urate levels". Nature. 417 (6887): 447–52. Bibcode:2002Natur.417..447E. doi:10.1038/nature742. PMID 12024214. S2CID 4417844.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197891 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061742 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SLC22A12 solute carrier family 22 (organic anion/cation transporter), member 12".

[pmid12024214-6] Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H (May 2002). "Molecular identification of a renal urate anion exchanger that regulates blood urate levels". Nature. 417 (6887): 447–52. Bibcode:2002Natur.417..447E. doi:10.1038/nature742. PMID 12024214. S2CID 4417844.

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