SLC46A3

SLC46A3
Identifiers
AliasesSLC46A3, FKSG16, SLC46A3 (gene), solute carrier family 46 member 3
External IDsOMIM: 616764; MGI: 1918956; HomoloGene: 41733; GeneCards: SLC46A3; OMA:SLC46A3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

283537

71706

Ensembl

ENSG00000139508

ENSMUSG00000029650

UniProt

Q7Z3Q1

Q9DC26

RefSeq (mRNA)

NM_001135919
NM_181785
NM_001347960

NM_027872
NM_001357002

RefSeq (protein)

NP_001129391
NP_861450
NP_001334889

NP_082148
NP_001343931

Location (UCSC)Chr 13: 28.7 – 28.72 MbChr 5: 147.82 – 147.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 46 member 3 (SLC46A3) is a protein that in humans is encoded by the SLC46A3 gene.[5] Also referred to as FKSG16, the protein belongs to the major facilitator superfamily (MFS) and SLC46A family.[6] Most commonly found in the plasma membrane and endoplasmic reticulum (ER), SLC46A3 is a multi-pass membrane protein with 11 α-helical transmembrane domains.[7][8] It is mainly involved in the transport of small molecules across the membrane through the substrate translocation pores featured in the MFS domain.[9][10] The protein is associated with breast and prostate cancer, hepatocellular carcinoma (HCC), papilloma, glioma, obesity, and SARS-CoV.[11][12][13][14][15][16] Based on the differential expression of SLC46A3 in antibody-drug conjugate (ADC)-resistant cells and certain cancer cells, current research is focused on the potential of SLC46A3 as a prognostic biomarker and therapeutic target for cancer.[17] While protein abundance is relatively low in humans, high expression has been detected particularly in the liver, small intestine, and kidney.[18][19]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139508 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029650 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "SLC46A3". NCBI (National Center for Biotechnology Information) Gene.
  6. ^ "SLC46A3 Gene". GeneCards The Human Gene Database.
  7. ^ Nakai K, Horton P (2007). "Computational Prediction of Subcellular Localization". Protein Targeting Protocols. Methods in Molecular Biology. Vol. 390. Totowa, NJ: Humana Press. pp. 429–466. doi:10.1007/1-59745-466-4_29. ISBN 978-1-58829-702-0.
  8. ^ Cite error: The named reference :7 was invoked but never defined (see the help page).
  9. ^ "SLC46A3". OMIM (Online Mendelian Inheritance in Man).
  10. ^ "MFS". NCBI (National Center for Biotechnology Information) CDD (Conserved Domain Database).
  11. ^ Li G, Guo J, Shen BQ, Yadav DB, Sliwkowski MX, Crocker LM, et al. (July 2018). "Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells". Molecular Cancer Therapeutics. 17 (7): 1441–1453. doi:10.1158/1535-7163.mct-17-0296. PMID 29695635.
  12. ^ Kanaoka R, Kushiyama A, Seno Y, Nakatsu Y, Matsunaga Y, Fukushima T, et al. (2015-06-03). "Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines". PLOS ONE. 10 (6): e0127467. Bibcode:2015PLoSO..1027467K. doi:10.1371/journal.pone.0127467. PMC 4454534. PMID 26039047.
  13. ^ Zhao Q, Zheng B, Meng S, Xu Y, Guo J, Chen LJ, et al. (June 2019). "Increased expression of SLC46A3 to oppose the progression of hepatocellular carcinoma and its effect on sorafenib therapy". Biomedicine & Pharmacotherapy. 114: 108864. doi:10.1016/j.biopha.2019.108864. PMID 30981107.
  14. ^ "SLC46A3 Polyclonal Antibody". ThermoFisher Scientific.
  15. ^ Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF (2012-12-14). "Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population". PLOS ONE. 7 (12): e51954. Bibcode:2012PLoSO...751954C. doi:10.1371/journal.pone.0051954. PMC 3522587. PMID 23251661.
  16. ^ Pfefferle S, Schöpf J, Kögl M, Friedel CC, Müller MA, Carbajo-Lozoya J, et al. (October 2011). "The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors". PLOS Pathogens. 7 (10): e1002331. doi:10.1371/journal.ppat.1002331. PMC 3203193. PMID 22046132.
  17. ^ Hamblett KJ, Jacob AP, Gurgel JL, Tometsko ME, Rock BM, Patel SK, et al. (December 2015). "SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm". Cancer Research. 75 (24): 5329–40. doi:10.1158/0008-5472.can-15-1610. PMID 26631267.
  18. ^ Fagerberg L, Hallström BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, et al. (February 2014). "Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics". Molecular & Cellular Proteomics. 13 (2): 397–406. doi:10.1074/mcp.m113.035600. PMC 3916642. PMID 24309898.
  19. ^ Duff MO, Olson S, Wei X, Garrett SC, Osman A, Bolisetty M, Plocik A, Celniker SE, Graveley BR (May 2015). "Genome-wide identification of zero nucleotide recursive splicing in Drosophila". Nature. 521 (7552): 376–9. Bibcode:2015Natur.521..376D. doi:10.1038/nature14475. PMC 4529404. PMID 25970244.