SMC2

SMC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4U4P
Identifiers
Aliases	SMC2, CAP-E, CAPE, SMC-2, SMC2L1, structural maintenance of chromosomes 2
External IDs	OMIM: 605576; MGI: 106067; HomoloGene: 4705; GeneCards: SMC2; OMA:SMC2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	104,141,419 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	52,488,260 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; testicle; ; ganglionic eminence; ; gonad; ; Achilles tendon; ; secondary oocyte; ; sperm; ; trabecular bone; ; bone marrow; ; bone marrow cells;
	Top expressed in
	tail of embryo; ; genital tubercle; ; primitive streak; ; abdominal wall; ; maxillary prominence; ; fetal liver hematopoietic progenitor cell; ; mandibular prominence; ; vas deferens; ; dermis; ; migratory enteric neural crest cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; protein heterodimerization activity; ATP binding; single-stranded DNA binding;
Cellular component	cytoplasm; cytosol; chromosome; nucleoplasm; condensin complex; nuclear chromosome; nucleolus; extracellular exosome; condensed chromosome; nucleus;
Biological process	kinetochore organization; meiotic chromosome condensation; chromosome organization; meiotic chromosome segregation; cell division; chromosome condensation; cell cycle; mitotic chromosome condensation;
	Sources:Amigo / QuickGO
Orthologs
	10592
	14211
	ENSG00000136824
	ENSMUSG00000028312
	O95347; Q05D74
	Q8CG48
	NM_001042550; NM_001042551; NM_001265602; NM_006444
	NM_001301412; NM_008017
	NP_001036015; NP_001036016; NP_001252531; NP_006435; NP_006435.2
	NP_001288341; NP_032043
	Wikidata
View/Edit Human	View/Edit Mouse

Structural maintenance of chromosomes protein 2 (SMC-2), also known as chromosome-associated protein E (CAP-E), is a protein that in humans is encoded by the SMC2 gene.^[5]^[6] SMC2 is part of the SMC protein family and is a core subunit of condensin I and II, large protein complexes involved in chromosome condensation, overall organization.^[7] Several studies have demonstrated the necessity of SMC2 for cell division and proliferation.^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136824 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028312 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schmiesing JA, Ball AR, Gregson HC, Alderton JM, Zhou S, Yokomori K (Oct 1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics". Proceedings of the National Academy of Sciences of the United States of America. 95 (22): 12906–11. Bibcode:1998PNAS...9512906S. doi:10.1073/pnas.95.22.12906. PMC 23650. PMID 9789013.
^ "Entrez Gene: SMC2 structural maintenance of chromosomes 2".
^ Eeftens, Jorine M.; Katan, Allard J.; Kschonsak, Marc; Hassler, Markus; de Wilde, Liza; Dief, Essam M.; Haering, Christian H.; Dekker, Cees (2016-03-01). "Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic". Cell Reports. 14 (8): 1813–1818. doi:10.1016/j.celrep.2016.01.063. ISSN 2211-1247. PMC 4785793. PMID 26904946.
^ Li, Xixi; Song, Guili; Zhao, Yasong; Ren, Jing; Li, Qing; Cui, Zongbin (September 2021). "Functions of SMC2 in the Development of Zebrafish Liver". Biomedicines. 9 (9): 1240. doi:10.3390/biomedicines9091240. ISSN 2227-9059. PMC 8465584. PMID 34572426.
^ Dávalos, Verónica; Súarez-López, Lucía; Castaño, Julio; Messent, Anthea; Abasolo, Ibane; Fernandez, Yolanda; Guerra-Moreno, Angel; Espín, Eloy; Armengol, Manel; Musulen, Eva; Ariza, Aurelio; Sayós, Joan; Arango, Diego; Schwartz, Simó (2012-12-21). "Human SMC2 Protein, a Core Subunit of Human Condensin Complex, Is a Novel Transcriptional Target of the WNT Signaling Pathway and a New Therapeutic Target *". Journal of Biological Chemistry. 287 (52): 43472–43481. doi:10.1074/jbc.M112.428466. ISSN 0021-9258. PMC 3527934. PMID 23095742.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136824 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028312 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9789013-5] Schmiesing JA, Ball AR, Gregson HC, Alderton JM, Zhou S, Yokomori K (Oct 1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics". Proceedings of the National Academy of Sciences of the United States of America. 95 (22): 12906–11. Bibcode:1998PNAS...9512906S. doi:10.1073/pnas.95.22.12906. PMC 23650. PMID 9789013.

[entrez-6] "Entrez Gene: SMC2 structural maintenance of chromosomes 2".

[:0-7] Eeftens, Jorine M.; Katan, Allard J.; Kschonsak, Marc; Hassler, Markus; de Wilde, Liza; Dief, Essam M.; Haering, Christian H.; Dekker, Cees (2016-03-01). "Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic". Cell Reports. 14 (8): 1813–1818. doi:10.1016/j.celrep.2016.01.063. ISSN 2211-1247. PMC 4785793. PMID 26904946.

[8] Li, Xixi; Song, Guili; Zhao, Yasong; Ren, Jing; Li, Qing; Cui, Zongbin (September 2021). "Functions of SMC2 in the Development of Zebrafish Liver". Biomedicines. 9 (9): 1240. doi:10.3390/biomedicines9091240. ISSN 2227-9059. PMC 8465584. PMID 34572426.

[:1-9] Dávalos, Verónica; Súarez-López, Lucía; Castaño, Julio; Messent, Anthea; Abasolo, Ibane; Fernandez, Yolanda; Guerra-Moreno, Angel; Espín, Eloy; Armengol, Manel; Musulen, Eva; Ariza, Aurelio; Sayós, Joan; Arango, Diego; Schwartz, Simó (2012-12-21). "Human SMC2 Protein, a Core Subunit of Human Condensin Complex, Is a Novel Transcriptional Target of the WNT Signaling Pathway and a New Therapeutic Target *". Journal of Biological Chemistry. 287 (52): 43472–43481. doi:10.1074/jbc.M112.428466. ISSN 0021-9258. PMC 3527934. PMID 23095742.

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