SMUG1

SMUG1
Identifiers
AliasesSMUG1, FDG, HMUDG, UNG3, single-strand-selective monofunctional uracil-DNA glycosylase 1
External IDsOMIM: 607753; MGI: 1918976; HomoloGene: 8629; GeneCards: SMUG1; OMA:SMUG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_027885

RefSeq (protein)

NP_082161

Location (UCSC)n/aChr 15: 103.06 – 103.08 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Single-strand selective monofunctional uracil DNA glycosylase is an enzyme that in humans is encoded by the SMUG1 gene.[4][5][6] SMUG1 is a glycosylase that removes uracil from single- and double-stranded DNA in nuclear chromatin, thus contributing to base excision repair.[6]

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036061Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Haushalter KA, Todd Stukenberg MW, Kirschner MW, Verdine GL (February 1999). "Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors". Current Biology. 9 (4): 174–85. doi:10.1016/S0960-9822(99)80087-6. PMID 10074426. S2CID 13930983.
  5. ^ Boorstein RJ, Cummings A, Marenstein DR, Chan MK, Ma Y, Neubert TA, Brown SM, Teebor GW (November 2001). "Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1". The Journal of Biological Chemistry. 276 (45): 41991–7. doi:10.1074/jbc.M106953200. PMID 11526119.
  6. ^ a b "Entrez Gene: SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1".