SNAP25

SNAP25
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KIL, 1XTG, 3DDA, 3RK2, 3RK3, 3RL0, 3ZUR, 2N1T, 3DDB
Identifiers
Aliases	SNAP25, CMS18, RIC-4, RIC4, SEC9, SNAP, SNAP-25, bA416N4.2, dJ1068F16.2, SUP, synaptosome associated protein 25kDa, synaptosome associated protein 25
External IDs	OMIM: 600322; MGI: 98331; HomoloGene: 13311; GeneCards: SNAP25; OMA:SNAP25 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p12.2 Start 10,172,395 bp[1] End 10,308,258 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F3|2 67.56 cM Start 136,555,373 bp[2] End 136,624,348 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum cerebellar vermis superior frontal gyrus Brodmann area 23 orbitofrontal cortex primary visual cortex lateral nuclear group of thalamus Top expressed in cerebellar vermis lobe of cerebellum pontine nuclei medial dorsal nucleus medial vestibular nucleus subiculum prefrontal cortex lateral geniculate nucleus primary motor cortex medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNAP receptor activity calcium-dependent protein binding protein binding SNARE binding syntaxin-1 binding voltage-gated potassium channel activity syntaxin binding Cellular component cytoplasm vesicle cytosol membrane growth cone myelin sheath BLOC-1 complex voltage-gated potassium channel complex plasma membrane synapse synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex cell junction trans-Golgi network SNARE complex perinuclear region of cytoplasm neuron projection synaptic vesicle presynaptic membrane axon specific granule membrane somatodendritic compartment tertiary granule membrane postsynapse extrinsic component of cytoplasmic side of plasma membrane cytoskeleton glutamatergic synapse Biological process associative learning regulation of neuron projection development synaptic vesicle docking locomotory behavior regulation of insulin secretion synaptic vesicle exocytosis synaptic vesicle fusion to presynaptic active zone membrane glutamate secretion neurotransmitter uptake synaptic vesicle priming regulation of establishment of protein localization neurotransmitter secretion long-term potentiation chemical synaptic transmission positive regulation of synaptic plasticity neutrophil degranulation short-term synaptic potentiation exocytic insertion of neurotransmitter receptor to postsynaptic membrane neurotransmitter receptor internalization exocytosis vesicle fusion potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6616 20614 Ensembl ENSG00000132639 ENSMUSG00000027273 UniProt P60880 P60879 RefSeq (mRNA) NM_003081 NM_130811 NM_001322902 NM_001322903 NM_001322904 NM_001322905 NM_001322906 NM_001322907 NM_001322908 NM_001322909 NM_001322910 NM_011428 NM_001291056 NM_001355254 NM_001355255 RefSeq (protein) NP_001309831 NP_001309832 NP_001309833 NP_001309834 NP_001309835 NP_001309836 NP_001309837 NP_001309838 NP_001309839 NP_003072 NP_570824 NP_001277985 NP_035558 NP_001342183 NP_001342184 Location (UCSC) Chr 20: 10.17 – 10.31 Mb Chr 2: 136.56 – 136.62 Mb PubMed search [3] [4]
Wikidata
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Synaptosomal-Associated Protein, 25kDa (SNAP-25) is a Target Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein Receptor (t-SNARE) protein encoded by the SNAP25 gene found on chromosome 20p12.2 in humans.^[5][6] SNAP-25 is a component of the trans-SNARE complex, which accounts for membrane fusion specificity and directly executes fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together.^[7]